Biocatalysis in the Swiss Manufacturing Environment

Biocatalysis has undergone a remarkable transition in the last two decades, from being considered a niche technology to playing a much more relevant role in organic synthesis today. Advances in molecular biology and bioinformatics, and the decreasing costs for gene synthesis and sequencing contribut...

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Bibliographic Details
Published in:Catalysts 2020-12, Vol.10 (12), p.1420
Main Authors: Hecht, Katrin, Meyer, Hans-Peter, Wohlgemuth, Roland, Buller, Rebecca
Format: Article
Language:English
Subjects:
Antibiotics
Bioinformatics
Biotechnology industry
Catalysts
Chemical industry
Chemical reactions
Chemical synthesis
Coronaviruses
Cost control
Cost estimates
COVID-19
drug shortage
enzyme technology
Enzymes
Gene sequencing
Generic drugs
Industrial applications
industrial biocatalysis
Initiatives
Innovations
Manufacturing
Molecular biology
Organic chemicals
Pandemics
Pharmaceutical industry
Sustainable development
Switzerland
Trends
Viral diseases
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Summary:Biocatalysis has undergone a remarkable transition in the last two decades, from being considered a niche technology to playing a much more relevant role in organic synthesis today. Advances in molecular biology and bioinformatics, and the decreasing costs for gene synthesis and sequencing contribute to the growing success of engineered biocatalysts in industrial applications. However, the incorporation of biocatalytic process steps in new or established manufacturing routes is not always straightforward. To realize the full synthetic potential of biocatalysis for the sustainable manufacture of chemical building blocks, it is therefore important to regularly analyze the success factors and existing hurdles for the implementation of enzymes in large scale small molecule synthesis. Building on our previous analysis of biocatalysis in the Swiss manufacturing environment, we present a follow-up study on how the industrial biocatalysis situation in Switzerland has evolved in the last four years. Considering the current industrial landscape, we record recent advances in biocatalysis in Switzerland as well as give suggestions where enzymatic transformations may be valuably employed to address some of the societal challenges we face today, particularly in the context of the current Coronavirus disease 2019 (COVID-19) pandemic.
ISSN:2073-4344
2073-4344
DOI:10.3390/catal10121420