Response of patients with chest tightness variant asthma with routine asthma treatment regimen: A 1‐year multicenter, prospective, real‐world study

• Published in: Clinical and translational medicine 2020-09, Vol.10 (5), p.e178-n/a
• Main Authors: Yan, Fugui, Li, Wen, Guan, Wei‐jie, Chen, Min, Qiu, Chen, Tang, Wei, Liu, Xiansheng, Xiang, Xudong, Li, Jing, Jin, Meiling, Dai, Yuanrong, Chen, Ping, Wu, Xiaohong, Qiu, Zhongmin, Dong, Liang, Zhao, Limin, Lin, Xiaoping, Wu, Changgui, Wu, Bin, Yuan, Yalian, Shi, Fei, Zhang, Ting, Zhou, Jun, Xie, Min, Fang, Xiaoyu, Zhang, Hongliang, Xiao, Bing, Xian, Mo, Wang, Jian, Qiu, Zhangwei, Lin, Jie, Ji, Bingbing, Zhou, Yong, Li, Yu, Liu, Chunhong, Chen, Yiping, Zeng, Yiming, Liu, Lingli, Hua, Wen, Huang, Huaqiong, Zhou, Jiesen, Hu, Yue, Che, Luanqing, Ying, Songmin, Chen, Zhihua, Zhong, Nanshan, Shen, Huahao
• Format: Article
• Language: English
• Subjects: chest tightness variant asthma; inhaled corticosteroids; Letter to Editor; long‐acting beta‐agonists; real‐world study
• ISSN: 2001-1326; 2001-1326
• DOI: 10.1002/ctm2.178

Background Asthmatic patients with chest tightness as their only presenting symptom (chest tightness variant asthma [CTVA]) have clinical characteristics of eosinophilic airway inflammation similar to those of classic asthma (CA); however, whether CTVA has similar response to antiasthma treatment as compared with CA remains unclear. Objective The response of 76 CTVA patients to standard asthma treatments with inhaled corticosteroids with long‐acting beta‐agonists was explored in a 52‐week multicenter, prospective, real‐world study. Results After 52 weeks of treatment with therapy regimens used for CA, the mean 5‐point Asthma Control Questionnaire (ACQ‐5) score decreased markedly from 1.38(first administration) to 0.71 (52 weeks, mean decrease: 0.674, 95%CI: 0.447‐0.900, P