The Roles of circRNAs in Liver Cancer Immunity

Circular RNAs (circRNAs) are stable covalently closed non-coding RNAs (ncRNAs). Many studies indicate that circRNAs are involved in the pathological and physiological processes of liver cancer. However, the functions of circRNAs in liver cancer immunity are less known. In this review, we summarized...

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Bibliographic Details
Published in:Frontiers in oncology 2021-02, Vol.10, p.598464-598464
Main Authors: Tang, Ying, Jiang, Mei, Jiang, Hai-Mei, Ye, Zeng Jie, Huang, Yu-Sheng, Li, Xiu-Shen, Qin, Bin-Yu, Zhou, Rui-Sheng, Pan, Hua-Feng, Zheng, Da-Yong
Format: Article
Language:English
Subjects:
circRNA
immune evasion
innate immunity
liver cancer
natural killer (NK) cells
Oncology
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Summary:Circular RNAs (circRNAs) are stable covalently closed non-coding RNAs (ncRNAs). Many studies indicate that circRNAs are involved in the pathological and physiological processes of liver cancer. However, the functions of circRNAs in liver cancer immunity are less known. In this review, we summarized the functions of circRNAs in liver cancer, including proliferative, metastasis and apoptosis, liver cancer stemness, cell cycle, immune evasion, glycolysis, angiogenesis, drug resistance/sensitizer, and senescence. Immune escape is considered to be one of the hallmarks of cancer development, and circRNA participates in the immune escape of liver cancer cells by regulating natural killer (NK) cell function. CircRNAs may provide new ideas for immunotherapy in liver cancer.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2020.598464