Systolic Blood Pressure and Outcome in Patients Admitted With Acute Heart Failure: An Analysis of Individual Patient Data From 4 Randomized Clinical Trials

BACKGROUND In acute heart failure (AHF), systolic blood pressure (SBP) is an important clinical variable. This study assessed the association between SBP and short-term and long-term outcomes in a large cohort of patients with AHF. METHODS AND RESULTS This is an analysis of 4 randomized controlled t...

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Bibliographic Details
Published in:Journal of the American Heart Association 2021-09, Vol.10 (18), p.e022288-e022288
Main Authors: Grand, Johannes, Miger, Kristina, Sajadieh, Ahmad, Køber, Lars, Torp-Pedersen, Christian, Ertl, Georg, López-Sendón, José, Pietro Maggioni, Aldo, Teerlink, John R, Sato, Naoki, Gimpelewicz, Claudio, Metra, Marco, Holbro, Thomas, Nielsen, Olav W
Format: Article
Language:English
Subjects:
acute heart failure
Aged
Aged, 80 and over
blood pressure
Blood Pressure - physiology
Heart Failure - physiopathology
Heart Failure - therapy
Humans
left ventricular ejection fraction
Middle Aged
mortality
Original Research
Patient Admission
Randomized Controlled Trials as Topic
Treatment Outcome
worsening heart failure
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Summary:BACKGROUND In acute heart failure (AHF), systolic blood pressure (SBP) is an important clinical variable. This study assessed the association between SBP and short-term and long-term outcomes in a large cohort of patients with AHF. METHODS AND RESULTS This is an analysis of 4 randomized controlled trials investigating serelaxin versus placebo in patients admitted with AHF and SBPs from 125 to 180 mm Hg. Outcomes were 180-day all-cause mortality and a composite end point of all-cause mortality, worsening heart failure, or hospital readmission for heart failure the first 14 days. Left ventricular ejection fraction (LVEF) was examined as LVEF
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.121.022288