Induction of inflammatory cytokines and toll-like receptors in chickens infected with avian H9N2 influenza virus

H9N2 influenza virus is endemic in many Asian countries and is regarded as a candidate for the next human pandemic. Knowledge of the induction of inflammatory responses and toll-like receptors (TLRs) in chickens infected with H9N2 is limited. Here, we show that H9N2 induces pro-inflammatory cytokine...

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Bibliographic Details
Published in:Veterinary research (Paris) 2011-05, Vol.42 (1), p.64-64, Article 64
Main Authors: Nang, Nguyen Tai, Lee, Joo Sub, Song, Byung Min, Kang, Young Myong, Kim, Hyun Soo, Seo, Sang Heui
Format: Article
Language:English
Subjects:
Animals
Avian influenza
Chickens
Cytokines
Cytokines - genetics
Cytokines - metabolism
humans
inflammation
Influenza A virus
Influenza A Virus, H9N2 Subtype - physiology
Influenza in Birds - immunology
Influenza in Birds - virology
interferon-alpha
Intestines - immunology
Intestines - virology
Lung - immunology
Lung - virology
pandemic
Physiological aspects
Poultry Diseases - immunology
Poultry Diseases - virology
Real-Time Polymerase Chain Reaction - veterinary
receptors
RNA, Messenger - genetics
RNA, Messenger - metabolism
Specific Pathogen-Free Organisms
Toll-like receptors
Toll-Like Receptors - genetics
Toll-Like Receptors - metabolism
Trachea - immunology
Trachea - virology
transforming growth factor beta
tumor necrosis factor-alpha
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Summary:H9N2 influenza virus is endemic in many Asian countries and is regarded as a candidate for the next human pandemic. Knowledge of the induction of inflammatory responses and toll-like receptors (TLRs) in chickens infected with H9N2 is limited. Here, we show that H9N2 induces pro-inflammatory cytokines such as transforming growth factor-beta 3; tumor necrosis factor-alpha; interferon-alpha, -beta, and gamma; and TLR 1, 2, 3, 4, 5, 7, and 15 in trachea, lung, and intestine of infected chickens. In the lung, TLR-15 was dominantly induced. Taken together, it seems that H9N2 infections efficiently induce inflammatory cytokines and TLRs in trachea, lung and intestine of chickens.
ISSN:1297-9716
0928-4249
1297-9716
DOI:10.1186/1297-9716-42-64