Virus-specific and shared gene expression signatures in immune cells after vaccination in response to influenza and vaccinia stimulation

In the vaccine era, individuals receive multiple vaccines in their lifetime. Host gene expression in response to antigenic stimulation is usually virus-specific; however, identifying shared pathways of host response across a wide spectrum of vaccine pathogens can shed light on the molecular mechanis...

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Bibliographic Details
Published in:Frontiers in immunology 2023-08, Vol.14, p.1168784
Main Authors: Quach, Huy Quang, Goergen, Krista M, Grill, Diane E, Haralambieva, Iana H, Ovsyannikova, Inna G, Poland, Gregory A, Kennedy, Richard B
Format: Article
Language:English
Subjects:
CD8-Positive T-Lymphocytes
gene expression signature
Humans
Immunology
influenza vaccine
Influenza Vaccines
Influenza, Human - genetics
pathway analysis
smallpox vaccine
Transcriptome
transcriptomic analysis
Vaccination
Vaccinia
Vaccinia virus - genetics
virus infection
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Summary:In the vaccine era, individuals receive multiple vaccines in their lifetime. Host gene expression in response to antigenic stimulation is usually virus-specific; however, identifying shared pathways of host response across a wide spectrum of vaccine pathogens can shed light on the molecular mechanisms/components which can be targeted for the development of broad/universal therapeutics and vaccines. We isolated PBMCs, monocytes, B cells, and CD8 T cells from the peripheral blood of healthy donors, who received both seasonal influenza vaccine (within
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2023.1168784