The Panic Disorder Respiratory Ratio: A Dimensional Approach to the Respiratory Subtype

The respiratory ratio is a dimensional construct of the respiratory subtype of panic disorder (PD). The respiratory subtype has been correlated with an increased sensitivity to CO2 inhalation, positive family history of PD and low comorbidity with depression. The objective of our study was to determ...

Full description

Saved in:
Bibliographic Details
Published in:Revista brasileira de psiquiatria 2013-03, Vol.35 (1), p.57-62
Main Authors: Freire, Rafael Christophe, Nascimento, Isabella, Valença, Alexandre Martins, Lopes, Fabiana Leão, Mezzasalma, Marco André, Melo Neto, Valfrido Leão de, Zin, Walter Araujo, Nardi, Antonio Egidio
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anxiety Disorders
Anxiety Disorders - physiopathology
Carbon Dioxide
Carbon Dioxide - physiology
Depressive Disorder
Female
Humans
Inhalation - physiology
Male
Middle Aged
Panic Attack
Panic Disorder - physiopathology
Predictive Value of Tests
PSYCHIATRY
Respiratory Rate - physiology
Respiratory System
Sex Distribution
Socioeconomic Factors
Surveys and Questionnaires
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The respiratory ratio is a dimensional construct of the respiratory subtype of panic disorder (PD). The respiratory subtype has been correlated with an increased sensitivity to CO2 inhalation, positive family history of PD and low comorbidity with depression. The objective of our study was to determine whether the respiratory ratio is correlated with CO2-induced panic attacks and other clinical and demographic features. We examined 91 patients with PD and submitted them to a double-breath 35% CO2 challenge test. The respiratory ratio was calculated based on the Diagnostic Symptom Questionnaire (DSQ) scores recorded in a diary in the days preceding the CO2 challenge. The scores of the respiratory symptoms were summed and divided by the total DSQ score. The respiratory ratio was correlated with CO2 sensitivity, and there was a non-statistically significant trend towards a correlation with a family history of PD. The positive correlation between the respiratory ratio and the anxiety elicited by the CO2 inhalation indicates that the intensity of respiratory symptoms may be proportional to the sensitivity to carbon dioxide.
ISSN:1516-4446
1809-452X
1809-452X
DOI:10.1016/j.rbp.2012.02.008