Cyclin D1 + large B-cell lymphoma with altered CCND1 and BCL-6 rearrangements: a diagnostic challenge

A subset of diffuse large B-cell lymphoma may show aberrant cyclin D1 expression, which may be confused with blastoid mantle cell lymphoma. These cases usually lack of CCND1 gene rearrangement. Duplication of CCND1 gene was attributed to some of the cases with cyclin D1 expression. The mechanism of...

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Bibliographic Details
Published in:Biomarker research 2019-06, Vol.7 (1), p.11-7, Article 11
Main Authors: Gao, Da, Liu, Zach
Format: Article
Language:English
Subjects:
B-cell lymphoma
BCL-6
Bcl-6 protein
Biopsy
Case Report
Case reports
CCND1
CCND1 gene
Cyclin D1
DLBCL
Gene expression
Gene rearrangement
Genes
Histology
Lymphocytes B
Lymphoma
Lymphomas
Mantle cell lymphoma
MCL
Medical prognosis
Morphology
Non-Hodgkin's lymphomas
Patients
Phenotypes
Stains & staining
Tumors
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Summary:A subset of diffuse large B-cell lymphoma may show aberrant cyclin D1 expression, which may be confused with blastoid mantle cell lymphoma. These cases usually lack of CCND1 gene rearrangement. Duplication of CCND1 gene was attributed to some of the cases with cyclin D1 expression. The mechanism of overexpression of CCND1 in other cases was not well documented. We report a case of diffuse large B-cell lymphoma with cyclin D1 expression. The underlying mechanism for cyclin D1 expression was due to an abnormal gene rearrangement involving BCL-6 and CCND1, which was different from most reported cases. Rare cases with similar genetic profile were reported and were classified as diffuse large B-cell lymphoma. The phenotype and genetic abnormalities of DLBCL with cyclin D1 overexpression can be complex and may be difficult to differentiate from blastoid and pleomorphic variants of mantle cell lymphoma.
ISSN:2050-7771
2050-7771
DOI:10.1186/s40364-019-0162-2