Efficacy of Acetazolamide in Refractory Epilepsy Management: A Quasi-Experimental Study

Objective: To assess the efficacy of Acetazolamide in refractory epilepsy management. Study Design: Quasi-experimental study. Place and Duration of Study: Outpatient Neurology Department, Allied Hospital, Faisalabad Pakistan, from Sep 2020 to Feb 2021. Methodology: Using a non-probability consecutiv...

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Bibliographic Details
Published in:Pakistan Armed Forces medical journal 2023-06, Vol.73 (3), p.674-77
Main Authors: Zamir, Muhammad Ahmed, Alam, Naveed, Iqbal, Javed, Rehman, Muhammad Ali, Raza, Baqar
Format: Article
Language:English
Subjects:
Acetazolamide
Convulsions & seizures
Data analysis
Disease
Drugs
Efficacy
Epilepsy
Mortality
Patients
Quasi-experimental methods
Refractory epilepsy
Resveratrol
Seizures (Medicine)
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Summary:Objective: To assess the efficacy of Acetazolamide in refractory epilepsy management. Study Design: Quasi-experimental study. Place and Duration of Study: Outpatient Neurology Department, Allied Hospital, Faisalabad Pakistan, from Sep 2020 to Feb 2021. Methodology: Using a non-probability consecutive sampling technique, 260 patients of either gender aged 18 to 60 years who met the criteria of refractory epilepsy were included in the study. Group-A (n=130) received oral Acetazolamide (250 mg twice a day) plus standard antiepileptic drugs, and Group-B (n=130) received a placebo plus standard antiepileptic drugs. Patients were assessed every four weeks for a six-month response to treatment. The outcome was assessed in terms of control of refractory epilepsy. Results: Acetazolamide was effective in 88(68.2%) patients compared to Placebo Group, which showed efficacy in 41(31.8%) patients (p-value was
ISSN:0030-9648
2411-8842
DOI:10.51253/pafmj.v73i3.6538