Neurodegeneration in Patients with Type 2 Diabetes Mellitus without Diabetic Retinopathy

Purpose. To evaluate neurodegeneration in patients with type 2 diabetes mellitus (DM2) without diabetic retinopathy and to assess the possible role of systemic vascular complications in retinal changes. Methods. Sixty eyes of 60 patients with DM2 and without any signs of diabetic retinopathy and 60...

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Bibliographic Details
Published in:Journal of ophthalmology 2019, Vol.2019 (2019), p.1-8
Main Authors: Satue, Maria, Polo, Vicente, Vilades, Elisa, Gil-Arribas, Laura, Melchor, Isabel, Cipres, Marta, Garcia-Martin, Elena, Rodrigo, Maria J.
Format: Article
Language:English
Subjects:
Age
Blood pressure
Body mass index
Diabetes
Diabetic neuropathy
Diabetic retinopathy
Disease
Edema
Glaucoma
Hypertension
Multiple sclerosis
Neurodegeneration
Patients
Retina
Software
Studies
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Summary:Purpose. To evaluate neurodegeneration in patients with type 2 diabetes mellitus (DM2) without diabetic retinopathy and to assess the possible role of systemic vascular complications in retinal changes. Methods. Sixty eyes of 60 patients with DM2 and without any signs of diabetic retinopathy and 60 eyes of 60 healthy controls underwent retinal evaluation using Spectralis optical coherence tomography. Macular ganglion cell layer (GCL) and retinal nerve fiber layer (RNFL) were evaluated. Peripapillary RNFL thickness was assessed using Glaucoma and Axonal Analytics applications. Comparison between patients with the presence/absence of systemic vascular complications and different disease duration was made. Results. Macular GCL was reduced in patients compared to controls (p
ISSN:2090-004X
2090-0058
DOI:10.1155/2019/1825819