Neurodegeneration in Patients with Type 2 Diabetes Mellitus without Diabetic Retinopathy

Purpose. To evaluate neurodegeneration in patients with type 2 diabetes mellitus (DM2) without diabetic retinopathy and to assess the possible role of systemic vascular complications in retinal changes. Methods. Sixty eyes of 60 patients with DM2 and without any signs of diabetic retinopathy and 60...

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Published in:Journal of ophthalmology 2019, Vol.2019 (2019), p.1-8
Main Authors: Satue, Maria, Polo, Vicente, Vilades, Elisa, Gil-Arribas, Laura, Melchor, Isabel, Cipres, Marta, Garcia-Martin, Elena, Rodrigo, Maria J.
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Language:English
Subjects:
Age
Blood pressure
Body mass index
Diabetes
Diabetic neuropathy
Diabetic retinopathy
Disease
Edema
Glaucoma
Hypertension
Multiple sclerosis
Neurodegeneration
Patients
Retina
Software
Studies
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container_issue 2019
container_start_page 1
container_title Journal of ophthalmology
container_volume 2019
creator Satue, Maria
Polo, Vicente
Vilades, Elisa
Gil-Arribas, Laura
Melchor, Isabel
Cipres, Marta
Garcia-Martin, Elena
Rodrigo, Maria J.
description Purpose. To evaluate neurodegeneration in patients with type 2 diabetes mellitus (DM2) without diabetic retinopathy and to assess the possible role of systemic vascular complications in retinal changes. Methods. Sixty eyes of 60 patients with DM2 and without any signs of diabetic retinopathy and 60 eyes of 60 healthy controls underwent retinal evaluation using Spectralis optical coherence tomography. Macular ganglion cell layer (GCL) and retinal nerve fiber layer (RNFL) were evaluated. Peripapillary RNFL thickness was assessed using Glaucoma and Axonal Analytics applications. Comparison between patients with the presence/absence of systemic vascular complications and different disease duration was made. Results. Macular GCL was reduced in patients compared to controls (p
doi_str_mv 10.1155/2019/1825819
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To evaluate neurodegeneration in patients with type 2 diabetes mellitus (DM2) without diabetic retinopathy and to assess the possible role of systemic vascular complications in retinal changes. Methods. Sixty eyes of 60 patients with DM2 and without any signs of diabetic retinopathy and 60 eyes of 60 healthy controls underwent retinal evaluation using Spectralis optical coherence tomography. Macular ganglion cell layer (GCL) and retinal nerve fiber layer (RNFL) were evaluated. Peripapillary RNFL thickness was assessed using Glaucoma and Axonal Analytics applications. Comparison between patients with the presence/absence of systemic vascular complications and different disease duration was made. Results. Macular GCL was reduced in patients compared to controls (p&lt;0.001). Differences in the macular RNFL thickness were only observed in the outer inferior sector (p=0.033). A reduction in the peripapillary RNFL (average, inferior, and inferotemporal thickness, p&lt;0.05 for all three) was observed in patients using both applications. Patients with chronic systemic vascular complications presented a reduction in the temporal RNFL (p=0.019) compared to patients without complications. The superotemporal RNFL thickness was thinner in patients with longer disease duration. Conclusions. Patients with type 2 DM without diabetic retinopathy and good metabolic control present neurodegeneration affecting neurons in the macular area and axons in different sectors of the optic disc. Systemic vascular complications contributed to further axonal damage in these patients, suggesting a possible role of subclinical ischaemia to retinal neurodegeneration in type 2 DM.</description><identifier>ISSN: 2090-004X</identifier><identifier>EISSN: 2090-0058</identifier><identifier>DOI: 10.1155/2019/1825819</identifier><identifier>PMID: 31485340</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Age ; Blood pressure ; Body mass index ; Diabetes ; Diabetic neuropathy ; Diabetic retinopathy ; Disease ; Edema ; Glaucoma ; Hypertension ; Multiple sclerosis ; Neurodegeneration ; Patients ; Retina ; Software ; Studies</subject><ispartof>Journal of ophthalmology, 2019, Vol.2019 (2019), p.1-8</ispartof><rights>Copyright © 2019 Elena Garcia-Martin et al.</rights><rights>COPYRIGHT 2019 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2019 Elena Garcia-Martin et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2019 Elena Garcia-Martin et al. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c635t-4247c6281c215503cb9ae4ba7a8fe7cdb85d1fd108e94308bcd772b6d2917a1d3</citedby><cites>FETCH-LOGICAL-c635t-4247c6281c215503cb9ae4ba7a8fe7cdb85d1fd108e94308bcd772b6d2917a1d3</cites><orcidid>0000-0002-1609-5994 ; 0000-0002-4009-3075 ; 0000-0001-6258-2489</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2407655143/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2407655143?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4021,25751,27921,27922,27923,37010,37011,44588,53789,53791,74896</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31485340$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Iacono, Pierluigi</contributor><contributor>Pierluigi Iacono</contributor><creatorcontrib>Satue, Maria</creatorcontrib><creatorcontrib>Polo, Vicente</creatorcontrib><creatorcontrib>Vilades, Elisa</creatorcontrib><creatorcontrib>Gil-Arribas, Laura</creatorcontrib><creatorcontrib>Melchor, Isabel</creatorcontrib><creatorcontrib>Cipres, Marta</creatorcontrib><creatorcontrib>Garcia-Martin, Elena</creatorcontrib><creatorcontrib>Rodrigo, Maria J.</creatorcontrib><title>Neurodegeneration in Patients with Type 2 Diabetes Mellitus without Diabetic Retinopathy</title><title>Journal of ophthalmology</title><addtitle>J Ophthalmol</addtitle><description>Purpose. To evaluate neurodegeneration in patients with type 2 diabetes mellitus (DM2) without diabetic retinopathy and to assess the possible role of systemic vascular complications in retinal changes. Methods. Sixty eyes of 60 patients with DM2 and without any signs of diabetic retinopathy and 60 eyes of 60 healthy controls underwent retinal evaluation using Spectralis optical coherence tomography. Macular ganglion cell layer (GCL) and retinal nerve fiber layer (RNFL) were evaluated. Peripapillary RNFL thickness was assessed using Glaucoma and Axonal Analytics applications. Comparison between patients with the presence/absence of systemic vascular complications and different disease duration was made. Results. Macular GCL was reduced in patients compared to controls (p&lt;0.001). Differences in the macular RNFL thickness were only observed in the outer inferior sector (p=0.033). A reduction in the peripapillary RNFL (average, inferior, and inferotemporal thickness, p&lt;0.05 for all three) was observed in patients using both applications. Patients with chronic systemic vascular complications presented a reduction in the temporal RNFL (p=0.019) compared to patients without complications. The superotemporal RNFL thickness was thinner in patients with longer disease duration. Conclusions. Patients with type 2 DM without diabetic retinopathy and good metabolic control present neurodegeneration affecting neurons in the macular area and axons in different sectors of the optic disc. Systemic vascular complications contributed to further axonal damage in these patients, suggesting a possible role of subclinical ischaemia to retinal neurodegeneration in type 2 DM.</description><subject>Age</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Diabetes</subject><subject>Diabetic neuropathy</subject><subject>Diabetic retinopathy</subject><subject>Disease</subject><subject>Edema</subject><subject>Glaucoma</subject><subject>Hypertension</subject><subject>Multiple sclerosis</subject><subject>Neurodegeneration</subject><subject>Patients</subject><subject>Retina</subject><subject>Software</subject><subject>Studies</subject><issn>2090-004X</issn><issn>2090-0058</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl1rHCEUhofS0oQ0d70uA4VSaDdRR2f0phDSr0D6QUkhd3JGz-wYZnWrMw377-t2t5ts6UUV9OB5fNXXUxRPKTmhVIhTRqg6pZIJSdWD4pARRWaECPlwF_Prg-I4pRuSW0W5EORxcZADKSpODovrzzjFYHGOHiOMLvjS-fJrjtCPqbx1Y19erZZYsvKtgxZHTOUnHAY3TptsmMZtxpnyWx59WMLYr54UjzoYEh5v56Pi-_t3V-cfZ5dfPlycn13OTF2JccYZb0zNJDUsv4dUplWAvIUGZIeNsa0UlnaWEomKV0S2xjYNa2vLFG2A2uqouNjo2gA3ehndAuJKB3D690KIcw0x321AXVcKqTRgATjvuAJFWAuEK9NApZTKWm82WsupXaA12YIIw57ofsa7Xs_DT103hElOssDLrUAMPyZMo164ZLJd4DFMSTMmBaVU8fVZz_9Cb8IUfbZKM06aWgjKqztqDvkBznchn2vWovqsJiR7kFumTv5B5W5x4Uzw2Lm8vrfhxb0NPcIw9ikM0_r_0z74egOaGFKK2O3MoESvK1CvK1BvKzDjz-4buIP_1FsGXm2A3nkLt-4_5TAz2MEdTbOPnFe_AI6j6lg</recordid><startdate>2019</startdate><enddate>2019</enddate><creator>Satue, Maria</creator><creator>Polo, Vicente</creator><creator>Vilades, Elisa</creator><creator>Gil-Arribas, Laura</creator><creator>Melchor, Isabel</creator><creator>Cipres, Marta</creator><creator>Garcia-Martin, Elena</creator><creator>Rodrigo, Maria J.</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley &amp; 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To evaluate neurodegeneration in patients with type 2 diabetes mellitus (DM2) without diabetic retinopathy and to assess the possible role of systemic vascular complications in retinal changes. Methods. Sixty eyes of 60 patients with DM2 and without any signs of diabetic retinopathy and 60 eyes of 60 healthy controls underwent retinal evaluation using Spectralis optical coherence tomography. Macular ganglion cell layer (GCL) and retinal nerve fiber layer (RNFL) were evaluated. Peripapillary RNFL thickness was assessed using Glaucoma and Axonal Analytics applications. Comparison between patients with the presence/absence of systemic vascular complications and different disease duration was made. Results. Macular GCL was reduced in patients compared to controls (p&lt;0.001). Differences in the macular RNFL thickness were only observed in the outer inferior sector (p=0.033). A reduction in the peripapillary RNFL (average, inferior, and inferotemporal thickness, p&lt;0.05 for all three) was observed in patients using both applications. Patients with chronic systemic vascular complications presented a reduction in the temporal RNFL (p=0.019) compared to patients without complications. The superotemporal RNFL thickness was thinner in patients with longer disease duration. Conclusions. Patients with type 2 DM without diabetic retinopathy and good metabolic control present neurodegeneration affecting neurons in the macular area and axons in different sectors of the optic disc. Systemic vascular complications contributed to further axonal damage in these patients, suggesting a possible role of subclinical ischaemia to retinal neurodegeneration in type 2 DM.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>31485340</pmid><doi>10.1155/2019/1825819</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-1609-5994</orcidid><orcidid>https://orcid.org/0000-0002-4009-3075</orcidid><orcidid>https://orcid.org/0000-0001-6258-2489</orcidid><oa>free_for_read</oa></addata></record>
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subjects Age
Blood pressure
Body mass index
Diabetes
Diabetic neuropathy
Diabetic retinopathy
Disease
Edema
Glaucoma
Hypertension
Multiple sclerosis
Neurodegeneration
Patients
Retina
Software
Studies
title Neurodegeneration in Patients with Type 2 Diabetes Mellitus without Diabetic Retinopathy
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