Blood monocyte levels predict the risk of acute exacerbations of chronic obstructive pulmonary disease: a retrospective case–control study

Monocytes were critical cells in the innate immune system. Monocyte recruitment to the lungs is a crucial process of pathophysiology in chronic obstructive pulmonary disease (COPD). Current evidence on the association between the occurrence of acute exacerbations of COPD (AECOPD) and monocytes was u...

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Bibliographic Details
Published in:Scientific reports 2022-12, Vol.12 (1), p.21057-21057, Article 21057
Main Authors: Lin, Ching-Hsiung, Li, Yi-Rong, Lin, Pei Ru, Wang, Bing-Yen, Lin, Sheng-Hao, Huang, Kuo-Yang, Kor, Chew-Teng
Format: Article
Language:English
Subjects:
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Blood
Bronchodilators
Case studies
Case-Control Studies
Chronic obstructive pulmonary disease
Cough
Humanities and Social Sciences
Humans
Hypertension
Immune system
Innate immunity
Leukocytes (eosinophilic)
Lung diseases
Lymphocytes
Malignancy
Monocytes
multidisciplinary
Obstructive lung disease
Patients
Pulmonary Disease, Chronic Obstructive
Regression analysis
Retrospective Studies
Science
Science (multidisciplinary)
Wheezing
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Summary:Monocytes were critical cells in the innate immune system. Monocyte recruitment to the lungs is a crucial process of pathophysiology in chronic obstructive pulmonary disease (COPD). Current evidence on the association between the occurrence of acute exacerbations of COPD (AECOPD) and monocytes was unclear. This study aimed to examine whether blood monocytes are associated with the occurrence of AECOPD and to determine the specific blood monocyte level to predict AECOPD. A retrospective case–control study was conducted at Changhua Christian Hospital. A total of 444 eligible patients with COPD were included between January 2017 and December 2019. Restricted cubic splines were used to analyze the nonlinear relationships between continuous white blood cell values and the occurrence of AECOPD. The association between monocytes and the occurrence of AECOPD was assessed using the logistic, lasso, and ridge regression models. Restricted cubic splines revealed nonlinear associations among the monocyte level, the continuous value of the eosinophil-to-lymphocyte ratio, and the occurrence of AECOPD. The lowest risk of occurrence of AECOPD ranged from 7.4 to 10%; 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-25520-8