Multitargeting Compounds: A Promising Strategy to Overcome Multi-Drug Resistant Tuberculosis

Tuberculosis is still an urgent global health problem, mainly due to the spread of multi-drug resistant strains, which lead to the need of new more efficient drugs. A strategy to overcome the problem of the resistance insurgence could be the polypharmacology approach, to develop single molecules tha...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2020-03, Vol.25 (5), p.1239
Main Authors: Stelitano, Giovanni, Sammartino, José Camilla, Chiarelli, Laurent Roberto
Format: Article
Language:English
Subjects:
Antibiotics
Antitubercular Agents - chemistry
Antitubercular Agents - therapeutic use
Drug Design
Drug development
Drug dosages
Drug interaction
Drug interactions
Drug resistance
drug targets
Drugs
Global health
HIV
Human immunodeficiency virus
Humans
Immune system
Infections
Molecular Targeted Therapy
Multidrug resistance
multitargeting compounds
Mutation
Mycobacterium tuberculosis - drug effects
Mycobacterium tuberculosis - pathogenicity
Pathogens
Patients
Polypharmacology
Review
Side effects
Success
Tuberculosis
Tuberculosis, Multidrug-Resistant - drug therapy
Tuberculosis, Multidrug-Resistant - microbiology
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Summary:Tuberculosis is still an urgent global health problem, mainly due to the spread of multi-drug resistant strains, which lead to the need of new more efficient drugs. A strategy to overcome the problem of the resistance insurgence could be the polypharmacology approach, to develop single molecules that act on different targets. Polypharmacology could have features that make it an approach more effective than the classical polypharmacy, in which different drugs with high affinity for one target are taken together. Firstly, for a compound that has multiple targets, the probability of development of resistance should be considerably reduced. Moreover, such compounds should have higher efficacy, and could show synergic effects. Lastly, the use of a single molecule should be conceivably associated with a lower risk of side effects, and problems of drug-drug interaction. Indeed, the multitargeting approach for the development of novel antitubercular drugs have gained great interest in recent years. This review article aims to provide an overview of the most recent and promising multitargeting antitubercular drug candidates.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25051239