Anticancer Effects of Propolis Extracts Obtained with the Cold Separation Method on PC-3 and DU-145 Prostate Cancer Cell Lines

Plant extracts are increasingly tested for their biological activity and interactions with neoplastic cells. One of such sources of biologically active substances is propolis. This product has been known for thousands of years and is widely used in alternative, folk medicine. Articles describing its...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-11, Vol.27 (23), p.8245
Main Authors: Gogacz, Marek, Peszke, Jerzy, Natorska-Chomicka, Dorota, Makuch-Kocka, Anna, Dos Santos Szewczyk, Katarzyna
Format: Article
Language:English
Subjects:
Androgens
Antigens
Apoptosis
Biological activity
Biological products
Cancer
Care and treatment
Cell Line
Cell Proliferation
Cell signaling
Cellular signal transduction
Cold
cold separation
Gene expression
Growth factors
Health promotion
Hormones - pharmacology
Humans
Kinases
Male
Metabolism
Metastasis
Methods
Mutation
Phosphorylation
Physiological aspects
Plant extracts
Plant Extracts - pharmacology
Propolis
Propolis - pharmacology
Prostate cancer
Prostatic Neoplasms - drug therapy
Proteins
Separation
Tumor cell lines
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Summary:Plant extracts are increasingly tested for their biological activity and interactions with neoplastic cells. One of such sources of biologically active substances is propolis. This product has been known for thousands of years and is widely used in alternative, folk medicine. Articles describing its effects on the metabolism and cell signaling pathways of neoplastic cells derived from different organs are also published more and more frequently. The purpose of our study was to evaluate the biological activity of propolis extract produced with the cold separation method into hormone-dependent and hormone-independent prostate cancer cell lines. In our study, the propolis extracts showed at least an inhibitory effect on the growth of PC-3 and DU-145 neoplastic cells. Our results suggest that propolis extracts obtained with the cold separation method may be considered as promising compounds for the production of health-promoting supplements.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27238245