Acceleration of Ethanol Metabolism by a Patented Bos taurus Isolated Alcohol Degradation Protein (ADP) on Acute Alcohol Consumption

Alcoholic beverages are among the most widely enjoyed leisure drinks around the world. However, irresponsible drinking habits can have detrimental effects on human health. Therefore, exploring strategies to alleviate discomfort following alcohol consumption would be beneficial for individuals who in...

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Bibliographic Details
Published in:Foods 2024-10, Vol.13 (19), p.3207
Main Authors: Tsoi, Bun, Zhang, Huan, So, Chun-Pang, Lam, Angel Ka-Kei, Poon, Christina Chui-Wa, Law, Sek-Lun, Wong, Bing-Lou, Seto, Sai-Wang
Format: Article
Language:English
Subjects:
Acetaldehyde
Alcohol
alcohol degradation
Alcohol use
Alcohol, Denatured
Alcoholic beverages
Beverages
Bos taurus
Communication
Degradation
Dehydrogenases
Drinking behavior
Drinking of alcoholic beverages
Effectiveness
Embryos
Ethanol
Gastrointestinal system
Gastrointestinal tract
hangover
Light
Liver
liver protection
Metabolism
Physiology
Protein turnover
Proteins
Toxicity
Toxicity testing
Zebrafish
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Summary:Alcoholic beverages are among the most widely enjoyed leisure drinks around the world. However, irresponsible drinking habits can have detrimental effects on human health. Therefore, exploring strategies to alleviate discomfort following alcohol consumption would be beneficial for individuals who inevitably need to consume alcohol. In this study, three different models were used to determine the efficacy of a patented alcohol degradation protein (ADP) extracted from on ethanol metabolism. In an ethanol-challenged HepG2 cell model, ADP significantly protected the cell from ethanol-induced toxicity. Subsequently, results demonstrated that ADP significantly alleviated the effect of ethanol, as reflected by the increased distance and activity time of zebrafish during the testing period. Additionally, in a rat model, ADP promoted ethanol degradation at 1 and 2 h after ethanol consumption. Mechanistic studies found that ADP treatment increased ADH and ALDH activity in the gastrointestinal tract. ADP also exhibited potent antioxidation effects by lowering HO-1 expression in the liver. In conclusion, we believe that ADP is a promising product for relieving hangover symptoms after ethanol consumption, with demonstrated safety and effectiveness at the recommended dosage.
ISSN:2304-8158
2304-8158
DOI:10.3390/foods13193207