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Acceleration of Ethanol Metabolism by a Patented Bos taurus Isolated Alcohol Degradation Protein (ADP) on Acute Alcohol Consumption
Alcoholic beverages are among the most widely enjoyed leisure drinks around the world. However, irresponsible drinking habits can have detrimental effects on human health. Therefore, exploring strategies to alleviate discomfort following alcohol consumption would be beneficial for individuals who in...
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| Published in: | Foods 2024-10, Vol.13 (19), p.3207 |
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| container_issue | 19 |
| container_start_page | 3207 |
| container_title | Foods |
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| creator | Tsoi, Bun Zhang, Huan So, Chun-Pang Lam, Angel Ka-Kei Poon, Christina Chui-Wa Law, Sek-Lun Wong, Bing-Lou Seto, Sai-Wang |
| description | Alcoholic beverages are among the most widely enjoyed leisure drinks around the world. However, irresponsible drinking habits can have detrimental effects on human health. Therefore, exploring strategies to alleviate discomfort following alcohol consumption would be beneficial for individuals who inevitably need to consume alcohol. In this study, three different models were used to determine the efficacy of a patented alcohol degradation protein (ADP) extracted from
on ethanol metabolism. In an ethanol-challenged HepG2 cell model, ADP significantly protected the cell from ethanol-induced toxicity. Subsequently, results demonstrated that ADP significantly alleviated the effect of ethanol, as reflected by the increased distance and activity time of zebrafish during the testing period. Additionally, in a rat model, ADP promoted ethanol degradation at 1 and 2 h after ethanol consumption. Mechanistic studies found that ADP treatment increased ADH and ALDH activity in the gastrointestinal tract. ADP also exhibited potent antioxidation effects by lowering HO-1 expression in the liver. In conclusion, we believe that ADP is a promising product for relieving hangover symptoms after ethanol consumption, with demonstrated safety and effectiveness at the recommended dosage. |
| doi_str_mv | 10.3390/foods13193207 |
| format | article |
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on ethanol metabolism. In an ethanol-challenged HepG2 cell model, ADP significantly protected the cell from ethanol-induced toxicity. Subsequently, results demonstrated that ADP significantly alleviated the effect of ethanol, as reflected by the increased distance and activity time of zebrafish during the testing period. Additionally, in a rat model, ADP promoted ethanol degradation at 1 and 2 h after ethanol consumption. Mechanistic studies found that ADP treatment increased ADH and ALDH activity in the gastrointestinal tract. ADP also exhibited potent antioxidation effects by lowering HO-1 expression in the liver. In conclusion, we believe that ADP is a promising product for relieving hangover symptoms after ethanol consumption, with demonstrated safety and effectiveness at the recommended dosage.</description><identifier>ISSN: 2304-8158</identifier><identifier>EISSN: 2304-8158</identifier><identifier>DOI: 10.3390/foods13193207</identifier><identifier>PMID: 39410241</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Acetaldehyde ; Alcohol ; alcohol degradation ; Alcohol use ; Alcohol, Denatured ; Alcoholic beverages ; Beverages ; Bos taurus ; Communication ; Degradation ; Dehydrogenases ; Drinking behavior ; Drinking of alcoholic beverages ; Effectiveness ; Embryos ; Ethanol ; Gastrointestinal system ; Gastrointestinal tract ; hangover ; Light ; Liver ; liver protection ; Metabolism ; Physiology ; Protein turnover ; Proteins ; Toxicity ; Toxicity testing ; Zebrafish</subject><ispartof>Foods, 2024-10, Vol.13 (19), p.3207</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c435t-f56c38fda3018af5c1a04be64ac23489cfcbe242e8b013caf23906ae48ed70ab3</cites><orcidid>0000-0003-4958-4222 ; 0000-0002-4569-876X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/3116601490/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3116601490?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39410241$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsoi, Bun</creatorcontrib><creatorcontrib>Zhang, Huan</creatorcontrib><creatorcontrib>So, Chun-Pang</creatorcontrib><creatorcontrib>Lam, Angel Ka-Kei</creatorcontrib><creatorcontrib>Poon, Christina Chui-Wa</creatorcontrib><creatorcontrib>Law, Sek-Lun</creatorcontrib><creatorcontrib>Wong, Bing-Lou</creatorcontrib><creatorcontrib>Seto, Sai-Wang</creatorcontrib><title>Acceleration of Ethanol Metabolism by a Patented Bos taurus Isolated Alcohol Degradation Protein (ADP) on Acute Alcohol Consumption</title><title>Foods</title><addtitle>Foods</addtitle><description>Alcoholic beverages are among the most widely enjoyed leisure drinks around the world. However, irresponsible drinking habits can have detrimental effects on human health. Therefore, exploring strategies to alleviate discomfort following alcohol consumption would be beneficial for individuals who inevitably need to consume alcohol. In this study, three different models were used to determine the efficacy of a patented alcohol degradation protein (ADP) extracted from
on ethanol metabolism. In an ethanol-challenged HepG2 cell model, ADP significantly protected the cell from ethanol-induced toxicity. Subsequently, results demonstrated that ADP significantly alleviated the effect of ethanol, as reflected by the increased distance and activity time of zebrafish during the testing period. Additionally, in a rat model, ADP promoted ethanol degradation at 1 and 2 h after ethanol consumption. Mechanistic studies found that ADP treatment increased ADH and ALDH activity in the gastrointestinal tract. ADP also exhibited potent antioxidation effects by lowering HO-1 expression in the liver. In conclusion, we believe that ADP is a promising product for relieving hangover symptoms after ethanol consumption, with demonstrated safety and effectiveness at the recommended dosage.</description><subject>Acetaldehyde</subject><subject>Alcohol</subject><subject>alcohol degradation</subject><subject>Alcohol use</subject><subject>Alcohol, Denatured</subject><subject>Alcoholic beverages</subject><subject>Beverages</subject><subject>Bos taurus</subject><subject>Communication</subject><subject>Degradation</subject><subject>Dehydrogenases</subject><subject>Drinking behavior</subject><subject>Drinking of alcoholic beverages</subject><subject>Effectiveness</subject><subject>Embryos</subject><subject>Ethanol</subject><subject>Gastrointestinal system</subject><subject>Gastrointestinal tract</subject><subject>hangover</subject><subject>Light</subject><subject>Liver</subject><subject>liver protection</subject><subject>Metabolism</subject><subject>Physiology</subject><subject>Protein turnover</subject><subject>Proteins</subject><subject>Toxicity</subject><subject>Toxicity testing</subject><subject>Zebrafish</subject><issn>2304-8158</issn><issn>2304-8158</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptks1v0zAYxiMEYtPYkSuyxGUcOvyVxDmh0A2oNEQPcLbe-KN1lcTFdpB25h_HoaOsCPtg6_HvfSw_foviJcHXjDX4rfVeR8JIwyiunxTnlGG-EKQUTx_tz4rLGHc4j4Ywwejz4ow1nGDKyXnxs1XK9CZAcn5E3qLbtIXR9-izSdD53sUBdfcI0BqSGZPR6L2PKMEUpohW0fcwa22v_DYX3ZhNAH3wWgefjBvRVXuzfoOy0KopmSO69GOchv2MviieWeijuXxYL4pvH26_Lj8t7r58XC3bu4XirEwLW1aKCauBYSLAlooA5p2pOCjKuGiUVZ2hnBrRYcIUWJojqsBwYXSNoWMXxergqz3s5D64AcK99ODkb8GHjYSQnOqNrJiuO91gXivFS0sbTlVldU1ryjqjdPZ6d_DaT91gtMrZBOhPTE9PRreVG_9DEsLrihKRHa4eHIL_PpmY5OBi_oseRuOnKBkhNa4Fpiyjr_9Bd34KY85qpqoKE97gv9QG8gvcaH2-WM2mshWE1mXDS56p6_9QeWozOOVHY13WTwoWhwIVfIzB2OMjCZZzF8qTLsz8q8fJHOk_Pcd-AbEc2C0</recordid><startdate>20241009</startdate><enddate>20241009</enddate><creator>Tsoi, Bun</creator><creator>Zhang, Huan</creator><creator>So, Chun-Pang</creator><creator>Lam, Angel Ka-Kei</creator><creator>Poon, Christina Chui-Wa</creator><creator>Law, Sek-Lun</creator><creator>Wong, Bing-Lou</creator><creator>Seto, Sai-Wang</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7T7</scope><scope>7X2</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>HCIFZ</scope><scope>M0K</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-4958-4222</orcidid><orcidid>https://orcid.org/0000-0002-4569-876X</orcidid></search><sort><creationdate>20241009</creationdate><title>Acceleration of Ethanol Metabolism by a Patented Bos taurus Isolated Alcohol Degradation Protein (ADP) on Acute Alcohol Consumption</title><author>Tsoi, Bun ; Zhang, Huan ; So, Chun-Pang ; Lam, Angel Ka-Kei ; Poon, Christina Chui-Wa ; Law, Sek-Lun ; Wong, Bing-Lou ; Seto, Sai-Wang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-f56c38fda3018af5c1a04be64ac23489cfcbe242e8b013caf23906ae48ed70ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acetaldehyde</topic><topic>Alcohol</topic><topic>alcohol degradation</topic><topic>Alcohol use</topic><topic>Alcohol, Denatured</topic><topic>Alcoholic beverages</topic><topic>Beverages</topic><topic>Bos taurus</topic><topic>Communication</topic><topic>Degradation</topic><topic>Dehydrogenases</topic><topic>Drinking behavior</topic><topic>Drinking of alcoholic beverages</topic><topic>Effectiveness</topic><topic>Embryos</topic><topic>Ethanol</topic><topic>Gastrointestinal system</topic><topic>Gastrointestinal tract</topic><topic>hangover</topic><topic>Light</topic><topic>Liver</topic><topic>liver protection</topic><topic>Metabolism</topic><topic>Physiology</topic><topic>Protein turnover</topic><topic>Proteins</topic><topic>Toxicity</topic><topic>Toxicity testing</topic><topic>Zebrafish</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsoi, Bun</creatorcontrib><creatorcontrib>Zhang, Huan</creatorcontrib><creatorcontrib>So, Chun-Pang</creatorcontrib><creatorcontrib>Lam, Angel Ka-Kei</creatorcontrib><creatorcontrib>Poon, Christina Chui-Wa</creatorcontrib><creatorcontrib>Law, Sek-Lun</creatorcontrib><creatorcontrib>Wong, Bing-Lou</creatorcontrib><creatorcontrib>Seto, Sai-Wang</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Agricultural Science Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>SciTech Premium Collection</collection><collection>Agriculture Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Foods</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsoi, Bun</au><au>Zhang, Huan</au><au>So, Chun-Pang</au><au>Lam, Angel Ka-Kei</au><au>Poon, Christina Chui-Wa</au><au>Law, Sek-Lun</au><au>Wong, Bing-Lou</au><au>Seto, Sai-Wang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acceleration of Ethanol Metabolism by a Patented Bos taurus Isolated Alcohol Degradation Protein (ADP) on Acute Alcohol Consumption</atitle><jtitle>Foods</jtitle><addtitle>Foods</addtitle><date>2024-10-09</date><risdate>2024</risdate><volume>13</volume><issue>19</issue><spage>3207</spage><pages>3207-</pages><issn>2304-8158</issn><eissn>2304-8158</eissn><abstract>Alcoholic beverages are among the most widely enjoyed leisure drinks around the world. However, irresponsible drinking habits can have detrimental effects on human health. Therefore, exploring strategies to alleviate discomfort following alcohol consumption would be beneficial for individuals who inevitably need to consume alcohol. In this study, three different models were used to determine the efficacy of a patented alcohol degradation protein (ADP) extracted from
on ethanol metabolism. In an ethanol-challenged HepG2 cell model, ADP significantly protected the cell from ethanol-induced toxicity. Subsequently, results demonstrated that ADP significantly alleviated the effect of ethanol, as reflected by the increased distance and activity time of zebrafish during the testing period. Additionally, in a rat model, ADP promoted ethanol degradation at 1 and 2 h after ethanol consumption. Mechanistic studies found that ADP treatment increased ADH and ALDH activity in the gastrointestinal tract. ADP also exhibited potent antioxidation effects by lowering HO-1 expression in the liver. In conclusion, we believe that ADP is a promising product for relieving hangover symptoms after ethanol consumption, with demonstrated safety and effectiveness at the recommended dosage.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39410241</pmid><doi>10.3390/foods13193207</doi><orcidid>https://orcid.org/0000-0003-4958-4222</orcidid><orcidid>https://orcid.org/0000-0002-4569-876X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acetaldehyde Alcohol alcohol degradation Alcohol use Alcohol, Denatured Alcoholic beverages Beverages Bos taurus Communication Degradation Dehydrogenases Drinking behavior Drinking of alcoholic beverages Effectiveness Embryos Ethanol Gastrointestinal system Gastrointestinal tract hangover Light Liver liver protection Metabolism Physiology Protein turnover Proteins Toxicity Toxicity testing Zebrafish |
| title | Acceleration of Ethanol Metabolism by a Patented Bos taurus Isolated Alcohol Degradation Protein (ADP) on Acute Alcohol Consumption |
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