Cough-aerosol cultures of Mycobacterium tuberculosis in the prediction of outcomes after exposure. A household contact study in Brazil

Mycobacterium tuberculosis cultures of cough-generated aerosols from patients with pulmonary tuberculosis (TB) are a quantitative method to measure infectiousness and to predict secondary outcomes in exposed contacts. However, their reproducibility has not been established. To evaluate the predictiv...

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Bibliographic Details
Published in:PloS one 2018-10, Vol.13 (10), p.e0206384-e0206384
Main Authors: Acuña-Villaorduña, Carlos, Schmidt-Castellani, Luiz Guilherme, Marques-Rodrigues, Patricia, White, Laura F, Hadad, David Jamil, Gaeddert, Mary, Ellner, Jerrold J, Fennelly, Kevin P, Palaci, Moises, Dietze, Reynaldo, Jones-López, Edward C
Format: Article
Language:English
Subjects:
Adult
Aerosols
Biology and Life Sciences
Brazil
Cough - microbiology
Culture Techniques
Disease transmission
Female
Housing
Humans
Male
Medicine and Health Sciences
Middle Aged
Mycobacterium tuberculosis
Mycobacterium tuberculosis - growth & development
Mycobacterium tuberculosis - physiology
People and places
Physical Sciences
Predictive Value of Tests
Tuberculosis, Pulmonary - microbiology
Tuberculosis, Pulmonary - transmission
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Summary:Mycobacterium tuberculosis cultures of cough-generated aerosols from patients with pulmonary tuberculosis (TB) are a quantitative method to measure infectiousness and to predict secondary outcomes in exposed contacts. However, their reproducibility has not been established. To evaluate the predictive value of colony-forming units (CFU) of M. tuberculosis in cough aerosols on secondary infection and disease in household contacts in Brazil. Adult sputum smear+ and culture+ pulmonary TB cases underwent a standard evaluation and were categorized according to aerosol CFU. We evaluated household contacts for infection at baseline and at 8 weeks with TST and IGRA, and secondary disease. We enrolled 48 index TB cases; 40% had negative aerosols, 27% low aerosols (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0206384