Calibrated scintigraphic imaging procedures improve quantitative assessment of the cardiac sympathetic nerve activity

The 123 I-labeled meta-iodobenzylguanidine (MIBG) is an analogue of noradrenaline that can evaluate cardiac sympathetic activity in scintigraphy. Quantitative analysis of 123 I-MIBG images has been verified in patients with heart failure and neurodegenerative diseases. However, quantitative results...

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Bibliographic Details
Published in:Scientific reports 2020-12, Vol.10 (1), p.21834-21834, Article 21834
Main Authors: Okuda, Koichi, Nakajima, Kenichi, Kitamura, Chiemi, Kirihara, Yumiko, Hashimoto, Mitsumasa, Kinuya, Seigo
Format: Article
Language:English
Subjects:
3-Iodobenzylguanidine - administration & dosage
692/700/1421/1771
692/700/1421/2160
Calibration
Congestive heart failure
Coronary artery disease
Female
Heart - diagnostic imaging
Heart - innervation
Humanities and Social Sciences
Humans
Male
Middle Aged
multidisciplinary
Neurodegenerative diseases
Norepinephrine
Radionuclide Imaging
Science
Science (multidisciplinary)
Scintigraphy
Standardization
Sympathetic nerves
Sympathetic Nervous System - diagnostic imaging
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Summary:The 123 I-labeled meta-iodobenzylguanidine (MIBG) is an analogue of noradrenaline that can evaluate cardiac sympathetic activity in scintigraphy. Quantitative analysis of 123 I-MIBG images has been verified in patients with heart failure and neurodegenerative diseases. However, quantitative results differ due to variations in scintigraphic imaging procedures. Here, we created and assessed the clinical feasibility of a calibration method for 123 I-MIBG imaging. The characteristics of scintigraphic imaging systems were determined using an acrylic calibration phantom to generate a multicenter phantom imaging database. Calibration factors corresponding to the scintigraphic imaging procedures were calculated from the database and applied to a clinical study. The results of this study showed that the calibrated analysis eliminated inter-institutional differences among normal individuals. In summary, our standardization methodology for 123 I-MIBG scintigraphy could provide the basis for improved diagnostic precision and better outcomes for patients.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-78917-8