Persicae Semen ameliorated acute myocardial ischemia in rats by regulating the PI3K/Akt/NF-κB pathway and arachidonic acid metabolism

• Published in: Journal of functional foods 2024-09, Vol.120, p.106388, Article 106388
• Main Authors: Fang, Cong, Jia, Zhixin, Ai, Jiajia, Xie, Yongyan, Zou, Chenyu, Zou, Guoming, Wu, Jun
• Format: Article
• Language: English
• Subjects: Acute myocardial ischemia; arachidonic acid; aspartate transaminase; blood serum; cardiac output; creatine kinase; herbal medicines; lactate dehydrogenase; mechanism of action; metabolism; Metabolomics; myocardial ischemia; Network pharmacology; Persicae Semen; pharmacodynamics; PI3K/Akt/ NF-κB
• ISSN: 1756-4646
• DOI: 10.1016/j.jff.2024.106388

[Display omitted] •12 components of Persicae semen (PS) were absorbed into plasma after administration, and PS could significantly improve the cardiac function of acute myocardial ischemia (AMI) rats.•The mechanism of PS was studied by means of systems biology (plasma component network pharmacology combined with metabolomics).•PS ameliorated AMI is associated with PI3K/Akt/NF-κB pathway and arachidonic acid metabolic. Persicae Semen is an edible Chinese herbal medicine that ameliorates myocardial ischemia. However, its pharmacodynamic properties and mechanisms of action remain unclear. This study aimed to investigate the ameliorative effect of Persicae Semen extract (PS) on acute myocardial ischemia (AMI) in rats and explore its mechanism of action. After the PS administration to rats, 12 compounds were identified in the plasma. PS can significantly improve cardiac function, regulate creatine kinase (CK), creatine kinase MB (CK-MB), cardiac troponin (cTn I), α-hydroxybutyrate dehydrogenase (HBDH), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) levels in the serum, and ameliorate the pathological injury of AMI in rats. Metabolomics and network pharmacology of components absorbed in to plasma showed that PS may regulate the PI3K/Akt/NF-κB pathway and arachidonic acid metabolism, then ameliorate myocardial ischemic injury. This study found that PS significantly improved cardiac function in rats with AMI, through the PI3K/Akt/NF-κB pathway and arachidonic acid metabolism.