Considerations on dosimetry for in vitro assessment of e-cigarette toxicity

Electronic cigarettes (or e-cigarettes) can be used as smoking cessation aid. Some studies tend to show that they are less hazardous than tobacco cigarettes, even if it does not mean they are completely safe. The huge variation in study designs assessing in vitro toxicity of e-cigarettes aerosol mak...

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Bibliographic Details
Published in:Respiratory research 2022-12, Vol.23 (1), p.358-358, Article 358
Main Authors: Forest, Valérie, Mercier, Clément, Pourchez, Jérémie
Format: Article
Language:English
Subjects:
Aerosols
Aerosols - toxicity
Analysis
Biological models (mathematics)
Cigarette smoking
Cigarettes
Design
Dosimeters
Dosimetry
Drug addiction
E-cigarette toxicity
Electronic cigarettes
Electronic Nicotine Delivery Systems
Health aspects
Health risk assessment
Health risks
Heterogeneity
In vitro inhalation toxicology
Life Sciences
Nicotine
Physiological doses
Physiology
Review
Smoking
Smoking Cessation
Smoking cessation products
Tobacco
Toxicity
Toxicity testing
Vaping
VOCs
Volatile organic compounds
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Summary:Electronic cigarettes (or e-cigarettes) can be used as smoking cessation aid. Some studies tend to show that they are less hazardous than tobacco cigarettes, even if it does not mean they are completely safe. The huge variation in study designs assessing in vitro toxicity of e-cigarettes aerosol makes it difficult to make comparisons and draw robust and irrefutable conclusions. In this paper, we review this heterogeneity (in terms of e-cigarette products, biological models, and exposure conditions) with a special focus on the wide disparity in the doses used as well as in the way they are expressed. Finally, we discuss the major issue of dosimetry and show how dosimetry tools enable to align data between different exposure systems or data from different laboratories and therefore allow comparisons to help further exploring the risk potential of e-cigarettes.
ISSN:1465-993X
1465-9921
1465-993X
1465-9921
DOI:10.1186/s12931-022-02286-1