Evolution and Antigenic Differentiation of Avian Influenza A(H7N9) Virus, China

We characterized the evolution and molecular characteristics of avian influenza A(H7N9) viruses isolated in China during 2021-2023. We systematically analyzed the 10-year evolution of the hemagglutinin gene to determine the evolutionary branch. Our results showed recent antigenic drift, providing cr...

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Bibliographic Details
Published in:Emerging infectious diseases 2024-06, Vol.30 (6), p.1218-1222
Main Authors: Liu, Yang, Chen, Yuhua, Yang, Zhiyi, Lin, Yaozhong, Fu, Siyuan, Chen, Junhong, Xu, Lingyu, Liu, Tengfei, Niu, Beibei, Huang, Qiuhong, Liu, Haixia, Zheng, Chaofeng, Liao, Ming, Jia, Weixin
Format: Article
Language:English
Subjects:
Animals
antigenic drift
Antigenic Variation
Antigens, Viral - genetics
Antigens, Viral - immunology
Avian influenza
Birds - virology
China
China - epidemiology
Epidemics
Epidemiology
evolution
Evolution, Molecular
Genetic aspects
Glycoproteins
H7N9
Health aspects
Hemagglutinin Glycoproteins, Influenza Virus - genetics
Hemagglutinin Glycoproteins, Influenza Virus - immunology
Humans
Infection
Influenza
Influenza A Virus, H7N9 Subtype - genetics
Influenza A Virus, H7N9 Subtype - immunology
Influenza in Birds - epidemiology
Influenza in Birds - virology
Influenza, Human - epidemiology
Influenza, Human - immunology
Influenza, Human - virology
Laboratories
Lectins
Medical research
Medicine, Experimental
Mutation
Phylogeny
Poultry
Prevention
Testing
Viral vaccines
Viruses
World health
zoonoses
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Summary:We characterized the evolution and molecular characteristics of avian influenza A(H7N9) viruses isolated in China during 2021-2023. We systematically analyzed the 10-year evolution of the hemagglutinin gene to determine the evolutionary branch. Our results showed recent antigenic drift, providing crucial clues for updating the H7N9 vaccine and disease prevention and control.
ISSN:1080-6040
1080-6059
1080-6059
DOI:10.3201/eid3006.230530