Palladium and organocatalysis: an excellent recipe for asymmetric synthesis

The dual activation of simple substrates by the combination of organocatalysis and palladium catalysis has been successfully applied in a variety of different asymmetric transformations. Thus, the asymmetric a-allylation of carbonyl compounds, a-fluorination of acyl derivatives, decarboxylative prot...

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Bibliographic Details
Published in:Molecules 2013-08, Vol.18 (9), p.10108-10121
Main Authors: Fernández-Ibañez, M Angeles, Maciá, Beatriz, Alonso, Diego A, Pastor, Isidro M
Format: Article
Language:English
Subjects:
Aldehydes - chemistry
Alkylation
Allyl Compounds - chemical synthesis
allylation
asymmetric synthesis
Catalysis
decarboxylative protonation
dual activation
fluorination
Halogenation
Hydrocarbons, Fluorinated - chemical synthesis
Models, Chemical
organocatalysis
palladium
Palladium - chemistry
Review
Stereoisomerism
tandem reaction
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Summary:The dual activation of simple substrates by the combination of organocatalysis and palladium catalysis has been successfully applied in a variety of different asymmetric transformations. Thus, the asymmetric a-allylation of carbonyl compounds, a-fluorination of acyl derivatives, decarboxylative protonation of β-dicarbonyl compounds, cyclization reactions of alkynyl carbonyl compounds and β-functionalization of aldehydes have been efficiently achieved employing this double-catalytic methodology.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules180910108