Improved Fracture Healing in Patients with Concomitant Traumatic Brain Injury: Proven or Not?

Over the last 3 decades, scientific evidence advocates an association between traumatic brain injury (TBI) and accelerated fracture healing. Multiple clinical and preclinical studies have shown an enhanced callus formation and an increased callus volume in patients, respectively, rats with concomita...

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Bibliographic Details
Published in:Mediators of Inflammation 2015-01, Vol.2015 (2015), p.664-677-060
Main Authors: Pape, Hans-Christoph, Andruszkow, Hagen, Poeze, Martijn, Kobbe, Philipp, Koopmans, Guido, Hofman, Martijn, Brink, Peter R. G.
Format: Article
Language:English
Subjects:
Blood-Brain Barrier
Bone marrow
Bone regeneration
Brain
Brain Injuries - immunology
Brain Injuries - physiopathology
Calcitonin Gene-Related Peptide - blood
Cell Death
Fracture Healing - physiology
Fractures
Humans
Inflammation - physiopathology
Injuries
Interleukin-6 - physiology
Leptin - blood
Mesenchymal Stromal Cells - cytology
Physiological aspects
Physiological research
Review
Transforming Growth Factor beta - physiology
Traumatic brain injury
Tumor necrosis factor-TNF
Vascular endothelial growth factor
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Summary:Over the last 3 decades, scientific evidence advocates an association between traumatic brain injury (TBI) and accelerated fracture healing. Multiple clinical and preclinical studies have shown an enhanced callus formation and an increased callus volume in patients, respectively, rats with concomitant TBI. Over time, different substances (cytokines, hormones, etc.) were in focus to elucidate the relationship between TBI and fracture healing. Until now, the mechanism behind this relationship is not fully clarified and a consensus on which substance plays the key role could not be attained in the literature. In this review, we will give an overview of current concepts and opinions on this topic published in the last decade and both clinical and pathophysiological theories will be discussed.
ISSN:0962-9351
1466-1861
DOI:10.1155/2015/204842