Marked Hyperbilirubinemia Associated with Primary Myelofibrosis Responsive to Ruxolitinib

Primary myelofibrosis (PMF) is a chronic myeloproliferative disorder seen in older adults which can present both with hepatosplenomegaly as well as mild nonspecific liver enzyme abnormalities. Mild elevations in bilirubin can occasionally be seen due to both intravascular hemolysis as well as extram...

Full description

Saved in:
Bibliographic Details
Published in:Case reports in hepatology 2022-05, Vol.2022, p.1-3
Main Authors: Sandhu, Sunny, Chaudhry, Hunza, Zhang, Sharon, Prajapati, Devang
Format: Article
Language:English
Subjects:
Ascites
Biopsy
Blood
Bone marrow
Case Report
Case reports
Enzymes
Etiology
Hematology
Hypertension
Liver
Older people
Patients
Spleen
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Primary myelofibrosis (PMF) is a chronic myeloproliferative disorder seen in older adults which can present both with hepatosplenomegaly as well as mild nonspecific liver enzyme abnormalities. Mild elevations in bilirubin can occasionally be seen due to both intravascular hemolysis as well as extramedullary hematopoiesis. Marked hyperbilirubinemia as a presenting sign of PMF progression, however, has not been reported. We present the case of a patient with a remote diagnosis of PMF, who presented with marked hyperbilirubinemia with a notable response to ruxolitinib.
ISSN:2090-6587
2090-6595
DOI:10.1155/2022/9630996