Stem Cells and Their Mediators - Next Generation Therapy for Bronchopulmonary Dysplasia

Bronchopulmonary dysplasia (BPD) remains a major complication of premature birth. Despite great achievements in perinatal medicine over the past decades, there is no treatment for BPD. Recent insights into the biology of stem/progenitor cells have ignited the hope of regenerating damaged organs. Ani...

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Bibliographic Details
Published in:Frontiers in medicine 2015-01, Vol.2, p.50-50
Main Authors: Möbius, Marius A, Thébaud, Bernard
Format: Article
Language:English
Subjects:
Bronchopulmonary Dysplasia
endothelial progenitor cells
Lung
Medicine
Mesenchymal Stromal Cells
Potency assay
Stem Cells
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Summary:Bronchopulmonary dysplasia (BPD) remains a major complication of premature birth. Despite great achievements in perinatal medicine over the past decades, there is no treatment for BPD. Recent insights into the biology of stem/progenitor cells have ignited the hope of regenerating damaged organs. Animal experiments revealed promising lung protection/regeneration with stem/progenitor cells in experimental models of BPD and led to first clinical studies in infants. However, these therapies are still experimental and knowledge on the exact mechanisms of action of these cells is limited. Furthermore, heterogeneity of the therapeutic cell populations and missing potency assays currently limit our ability to predict a cell product's efficacy. Here, we review the therapeutic potential of mesenchymal stromal, endothelial progenitor, and amniotic epithelial cells for BPD. Current knowledge on the mechanisms behind the beneficial effects of stem cells is briefly summarized. Finally, we discuss the obstacles constraining their transition from bench-to-bedside and present potential approaches to overcome them.
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2015.00050