Grindstone Chemistry: Design, One-Pot Synthesis, and Promising Anticancer Activity of Spiro[acridine-9,2'-indoline]-1,3,8-trione Derivatives against the MCF-7 Cancer Cell Line

In this study, the synthesis of one-pot 10-phenyl-3,4,6,7-tetrahydro-1 -spiro [acridine-9,2'-indoline]-1,3,8-trione derivatives was achieved via a four-component cyclocondensation reaction, which was carried out in solvent-free conditions, and using p-toluenesulfonic acid (p-TSA) as a catalyst....

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2020-12, Vol.25 (24), p.5862
Main Authors: Gobinath, Perumal, Packialakshmi, Ponnusamy, Daoud, Ali, Alarifi, Saud, Idhayadhulla, Akbar, Radhakrishnan, Surendrakumar
Format: Article
Language:English
Subjects:
Acridine
Antitumor activity
Cancer
Catalysts
Cell cycle
cyclocondensation
Cytotoxicity
grinding
indole
isatin
Mass spectra
p-TSA catalyst
solvent-free conditions
Solvents
Tumor cell lines
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Summary:In this study, the synthesis of one-pot 10-phenyl-3,4,6,7-tetrahydro-1 -spiro [acridine-9,2'-indoline]-1,3,8-trione derivatives was achieved via a four-component cyclocondensation reaction, which was carried out in solvent-free conditions, and using p-toluenesulfonic acid (p-TSA) as a catalyst. The product was confirmed by FT-IR, H-NMR, C-NMR, mass spectra, and elemental analysis. Furthermore, the anticancer activity was screened for all compounds. Among these compounds, compound was more effective (GI 0.01 µm) against MCF-7 cancer cell lines than standard and other compounds. Therefore, the objective of this study was achieved with a few promising molecules having been demonstrated to be potential anticancer agents.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25245862