Non-coding RNA basis of muscle atrophy

Muscle atrophy is a common complication of many chronic diseases including heart failure, cancer cachexia, aging, etc. Unhealthy habits and usage of hormones such as dexamethasone can also lead to muscle atrophy. However, the underlying mechanisms of muscle atrophy are not completely understood. Non...

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Bibliographic Details
Published in:Molecular therapy. Nucleic acids 2021-12, Vol.26, p.1066-1078
Main Authors: Liu, Qi, Deng, Jiali, Qiu, Yan, Gao, Juan, Li, Jin, Guan, Longfei, Lee, Hangil, Zhou, Qiulian, Xiao, Junjie
Format: Article
Language:English
Subjects:
aging
heart failure
lncRNA
microRNA
muscle atrophy
non-coding RNA
Review
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Summary:Muscle atrophy is a common complication of many chronic diseases including heart failure, cancer cachexia, aging, etc. Unhealthy habits and usage of hormones such as dexamethasone can also lead to muscle atrophy. However, the underlying mechanisms of muscle atrophy are not completely understood. Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs), play vital roles in muscle atrophy. This review mainly discusses the regulation of ncRNAs in muscle atrophy induced by various factors such as heart failure, cancer cachexia, aging, chronic obstructive pulmonary disease (COPD), peripheral nerve injury (PNI), chronic kidney disease (CKD), unhealthy habits, and usage of hormones; highlights the findings of ncRNAs as common regulators in multiple types of muscle atrophy; and summarizes current therapies and underlying mechanisms for muscle atrophy. This review will deepen the understanding of skeletal muscle biology and provide new strategies and insights into gene therapy for muscle atrophy. [Display omitted] Xiao and colleagues mainly discuss the regulation of ncRNAs in muscle atrophy induced by different factors, highlights ncRNAs as common regulators in multiple types of muscle atrophy and will provide new insights into gene therapy of muscle atrophy.
ISSN:2162-2531
2162-2531
DOI:10.1016/j.omtn.2021.10.010