Predictive modelling of level IIb lymph node metastasis in oral squamous cell carcinoma

• Published in: Scientific reports 2021-09, Vol.11 (1), p.17562-17562, Article 17562
• Main Authors: Yang, Hyunwoo, Son, Nak-Hoon, Lee, Sung Hwa, Kim, Dongwook, Kim, Hyung Jun, Cha, In-ho, Nam, Woong
• Format: Article
• Language: English
• Subjects: 631/67; 692/308; 692/4028; 692/499; 692/699; Cancer; Dissection; Female; Humanities and Social Sciences; Humans; Lymph Node Excision - methods; Lymph nodes; Lymphatic Metastasis; Lymphatic system; Male; Metastases; Metastasis; Middle Aged; Models, Statistical; Mouth Neoplasms - pathology; Mouth Neoplasms - surgery; multidisciplinary; Multivariate analysis; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - surgery; Neoplasm Staging; Nomograms; Oral cancer; Oral carcinoma; Oral squamous cell carcinoma; Patients; Prediction models; Retrospective Studies; Risk factors; Science; Science (multidisciplinary); Squamous cell carcinoma; Squamous Cell Carcinoma of Head and Neck - pathology; Squamous Cell Carcinoma of Head and Neck - surgery; Survival Rate
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-96827-1

The aim of the present study was to examine the conditions, characteristics, and risk factors of level IIb lymph node metastases in oral squamous cell carcinoma and to formulate surgical criteria for level IIb lymph node dissection. We analyzed clinical and pathological records for 541 oral squamous carcinoma patients in relation to level IIb metastasis. Univariate and multivariate analyses were performed to detect risk factors for level IIb lymph node metastasis; a predictive model was built based on multivariate analysis and tested in a validation group. Univariate and multivariate analyses using the training group indicated that level IIa metastasis and Lymphovascular permeation (LVP) were two independent risk factors for level IIb lymph node metastasis. This model was built and tested in a validation group, the area under the curve being 0.697 (P