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Predictive modelling of level IIb lymph node metastasis in oral squamous cell carcinoma
The aim of the present study was to examine the conditions, characteristics, and risk factors of level IIb lymph node metastases in oral squamous cell carcinoma and to formulate surgical criteria for level IIb lymph node dissection. We analyzed clinical and pathological records for 541 oral squamous...
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| Published in: | Scientific reports 2021-09, Vol.11 (1), p.17562-17562, Article 17562 |
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| creator | Yang, Hyunwoo Son, Nak-Hoon Lee, Sung Hwa Kim, Dongwook Kim, Hyung Jun Cha, In-ho Nam, Woong |
| description | The aim of the present study was to examine the conditions, characteristics, and risk factors of level IIb lymph node metastases in oral squamous cell carcinoma and to formulate surgical criteria for level IIb lymph node dissection. We analyzed clinical and pathological records for 541 oral squamous carcinoma patients in relation to level IIb metastasis. Univariate and multivariate analyses were performed to detect risk factors for level IIb lymph node metastasis; a predictive model was built based on multivariate analysis and tested in a validation group. Univariate and multivariate analyses using the training group indicated that level IIa metastasis and Lymphovascular permeation (LVP) were two independent risk factors for level IIb lymph node metastasis. This model was built and tested in a validation group, the area under the curve being 0.697 (P |
| doi_str_mv | 10.1038/s41598-021-96827-1 |
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We analyzed clinical and pathological records for 541 oral squamous carcinoma patients in relation to level IIb metastasis. Univariate and multivariate analyses were performed to detect risk factors for level IIb lymph node metastasis; a predictive model was built based on multivariate analysis and tested in a validation group. Univariate and multivariate analyses using the training group indicated that level IIa metastasis and Lymphovascular permeation (LVP) were two independent risk factors for level IIb lymph node metastasis. This model was built and tested in a validation group, the area under the curve being 0.697 (P < .0.001). The model’s sensitivity was 66.7% and specificity was 77.4%. Nomogram incorporating validated variables was developed for level IIb metastasis prediction. Expected survival probabilites were analysed to specify significance of model's variable on patients’ overall survival and recurrence. Level IIb dissection should be performed in patients with level IIa metastasis and LVP. However, thorough consideration of the oncologic safety of omitting level IIb dissection is compulsory.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-021-96827-1</identifier><identifier>PMID: 34475441</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/67 ; 692/308 ; 692/4028 ; 692/499 ; 692/699 ; Cancer ; Dissection ; Female ; Humanities and Social Sciences ; Humans ; Lymph Node Excision - methods ; Lymph nodes ; Lymphatic Metastasis ; Lymphatic system ; Male ; Metastases ; Metastasis ; Middle Aged ; Models, Statistical ; Mouth Neoplasms - pathology ; Mouth Neoplasms - surgery ; multidisciplinary ; Multivariate analysis ; Neoplasm Recurrence, Local - pathology ; Neoplasm Recurrence, Local - surgery ; Neoplasm Staging ; Nomograms ; Oral cancer ; Oral carcinoma ; Oral squamous cell carcinoma ; Patients ; Prediction models ; Retrospective Studies ; Risk factors ; Science ; Science (multidisciplinary) ; Squamous cell carcinoma ; Squamous Cell Carcinoma of Head and Neck - pathology ; Squamous Cell Carcinoma of Head and Neck - surgery ; Survival Rate</subject><ispartof>Scientific reports, 2021-09, Vol.11 (1), p.17562-17562, Article 17562</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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Level IIb dissection should be performed in patients with level IIa metastasis and LVP. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Hyunwoo</au><au>Son, Nak-Hoon</au><au>Lee, Sung Hwa</au><au>Kim, Dongwook</au><au>Kim, Hyung Jun</au><au>Cha, In-ho</au><au>Nam, Woong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictive modelling of level IIb lymph node metastasis in oral squamous cell carcinoma</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2021-09-02</date><risdate>2021</risdate><volume>11</volume><issue>1</issue><spage>17562</spage><epage>17562</epage><pages>17562-17562</pages><artnum>17562</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The aim of the present study was to examine the conditions, characteristics, and risk factors of level IIb lymph node metastases in oral squamous cell carcinoma and to formulate surgical criteria for level IIb lymph node dissection. We analyzed clinical and pathological records for 541 oral squamous carcinoma patients in relation to level IIb metastasis. Univariate and multivariate analyses were performed to detect risk factors for level IIb lymph node metastasis; a predictive model was built based on multivariate analysis and tested in a validation group. Univariate and multivariate analyses using the training group indicated that level IIa metastasis and Lymphovascular permeation (LVP) were two independent risk factors for level IIb lymph node metastasis. This model was built and tested in a validation group, the area under the curve being 0.697 (P < .0.001). The model’s sensitivity was 66.7% and specificity was 77.4%. Nomogram incorporating validated variables was developed for level IIb metastasis prediction. Expected survival probabilites were analysed to specify significance of model's variable on patients’ overall survival and recurrence. Level IIb dissection should be performed in patients with level IIa metastasis and LVP. However, thorough consideration of the oncologic safety of omitting level IIb dissection is compulsory.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>34475441</pmid><doi>10.1038/s41598-021-96827-1</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/67 692/308 692/4028 692/499 692/699 Cancer Dissection Female Humanities and Social Sciences Humans Lymph Node Excision - methods Lymph nodes Lymphatic Metastasis Lymphatic system Male Metastases Metastasis Middle Aged Models, Statistical Mouth Neoplasms - pathology Mouth Neoplasms - surgery multidisciplinary Multivariate analysis Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - surgery Neoplasm Staging Nomograms Oral cancer Oral carcinoma Oral squamous cell carcinoma Patients Prediction models Retrospective Studies Risk factors Science Science (multidisciplinary) Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - pathology Squamous Cell Carcinoma of Head and Neck - surgery Survival Rate |
| title | Predictive modelling of level IIb lymph node metastasis in oral squamous cell carcinoma |
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