M2 microglia-derived exosomes promote vascular remodeling in diabetic retinopathy

Diabetic retinopathy (DR) is a vision-threatening diabetic complication that is characterized by microvasculature impairment and immune dysfunction. The present study demonstrated that M2 microglia intensively participated in retinal microangiopathy in human diabetic proliferative membranes, mice re...

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Published in:Journal of nanobiotechnology 2024-02, Vol.22 (1), p.56-56, Article 56
Main Authors: Wang, Xingxing, Xu, Changlin, Bian, Cunxin, Ge, Pengfei, Lei, Jie, Wang, Jingfan, Xiao, Tianhao, Fan, Yuanyuan, Gu, Qinyuan, Li, Hong-Ying, Xu, Jingyi, Hu, Zizhong, Xie, Ping
Format: Article
Language:English
Subjects:
Angiogenesis
Apoptosis
Care and treatment
Cell growth
Cell proliferation
Cytokines
Diabetes
Diabetes mellitus
Diabetic retinopathy
Diagnosis
Digital cameras
Disease susceptibility
Endothelial cells
Evaluation
Exosomes
Glucose
Homeostasis
Metabolites
Microglia
Microscopy
Microvasculature
Permeability
Retina
Retinopathy
Streptozocin
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Summary:Diabetic retinopathy (DR) is a vision-threatening diabetic complication that is characterized by microvasculature impairment and immune dysfunction. The present study demonstrated that M2 microglia intensively participated in retinal microangiopathy in human diabetic proliferative membranes, mice retinas, retinas of mice with oxygen-induced retinopathy (OIR) mice, and retinas of streptozotocin-induced DR mice. Further in vivo and in vitro experiments showed that exosomes derived from M2 polarized microglia (M2-exo) could reduce pericyte apoptosis and promote endothelial cell proliferation, thereby promoting vascular remodeling and reducing vascular leakage from the diabetic retina. These effects were further enhanced by M2-exo that facilitated M2 polarization of retinal microglia. Collectively, the study demonstrated the capability of M2-exo to induce retinal microvascular remodeling, which may provide a new therapeutic strategy for the treatment of DR.
ISSN:1477-3155
1477-3155
DOI:10.1186/s12951-024-02330-w