A Review on the Synthesis and Chemical Transformation of Quinazoline 3-Oxides

The synthesis of quinazoline 3-oxides and their derivatives has attracted considerable attention due to their reactivity as intermediates in the synthesis of quinazoline analogues and their ring-expanded derivatives. Despite this, there is no comprehensive review dedicated to the synthesis and chemi...

Full description

Saved in:
Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-11, Vol.27 (22), p.7985
Main Author: Mphahlele, Malose J
Format: Article
Language:English
Subjects:
Acids
Antifungal agents
Benzodiazepines
Biological activity
Chemistry, Pharmaceutical
Free radicals
Humans
Hydrolysis
Intermediates
Iodine
Nitrogen
Oxides
pyrimidine
Pyrimidines
quinazoline oxides
Quinazolines
Research Personnel
Review
Reviews
synthesis
transformation
Transformations
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The synthesis of quinazoline 3-oxides and their derivatives has attracted considerable attention due to their reactivity as intermediates in the synthesis of quinazoline analogues and their ring-expanded derivatives. Despite this, there is no comprehensive review dedicated to the synthesis and chemical transformation of these biologically relevant azaaromatic oxides. This review aims to provide an up-to-date record of the synthesis of quinazoline 3-oxides and their chemical transformation. It is hoped that this information will help medicinal chemistry researchers to design and synthesize new derivatives or analogues to treat various diseases.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27227985