Episodic-like memory trace in awake replay of hippocampal place cell activity sequences

Episodic memory retrieval of events at a specific place and time is effective for future planning. Sequential reactivation of the hippocampal place cells along familiar paths while the animal pauses is well suited to such a memory retrieval process. It is, however, unknown whether this awake replay...

Full description

Saved in:
Bibliographic Details
Published in:eLife 2015-10, Vol.4, p.e08105-e08105
Main Author: Takahashi, Susumu
Format: Article
Language:English
Subjects:
Animals
awake replay
episodic-like memory
hippocampus
Hippocampus - cytology
Hippocampus - physiology
Memory, Episodic
Neurons - physiology
Neuroscience
place cell
Rats, Wistar
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Episodic memory retrieval of events at a specific place and time is effective for future planning. Sequential reactivation of the hippocampal place cells along familiar paths while the animal pauses is well suited to such a memory retrieval process. It is, however, unknown whether this awake replay represents events occurring along the path. Using a subtask switching protocol in which the animal experienced three subtasks as 'what' information in a maze, I here show that the replay represents a trial type, consisting of path and subtask, in terms of neuronal firing timings and rates. The actual trial type to be rewarded could only be reliably predicted from replays that occurred at the decision point. This trial-type representation implies that not only 'where and when' but also 'what' information is contained in the replay. This result supports the view that awake replay is an episodic-like memory retrieval process.
ISSN:2050-084X
2050-084X
DOI:10.7554/elife.08105