Exploitation of blood non-Newtonian properties for ultrasonic measurement of hematocrit

New processing techniques for manipulating blood and its components at a microfluidic scale are currently implemented. As for extracorporeal circulation, the in-line evaluation and monitoring of blood properties during these microfluidic techniques is a challenging task. Here, we show that the blood...

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Bibliographic Details
Published in:Scientific reports 2021-05, Vol.11 (1), p.10208-10208, Article 10208
Main Authors: Pialot, B., Gachelin, J., Provost, J., Couture, O.
Format: Article
Language:English
Subjects:
639/166/985
639/766/189
639/766/25/3927
Blood
Blood & organ donations
Conventions
Doppler effect
Hematocrit
Humanities and Social Sciences
Life Sciences
Microfluidics
multidisciplinary
Science
Science (multidisciplinary)
Separation techniques
Signal processing
Ultrasonic imaging
Ultrasound
Velocity
Viscosity
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Summary:New processing techniques for manipulating blood and its components at a microfluidic scale are currently implemented. As for extracorporeal circulation, the in-line evaluation and monitoring of blood properties during these microfluidic techniques is a challenging task. Here, we show that the blood hematocrit can be measured non-invasively in a sub-millimeter medical tube using the non-Newtonian behavior of blood velocity profile. This hematocrit measurement is demonstrated on human blood with a simple Doppler ultrasound system. Results show a mean measurement error of 4.6 ± 1.3%Hct for hematocrit up to 52% and for 5 s-long ultrasonic signals. The simplicity and the measurement scale of the approach make it highly valuable for measuring hematocrit in new blood separation techniques. The approach may have an impact on in-vitro blood processing in general.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-89704-4