Research progress of brain organoids in the field of diabetes

Human embryonic stem cells and human induced pluripotent stem cells may be used to create 3D tissues called brain organoids. They duplicate the physiological and pathological characteristics of human brain tissue more faithfully in terms of both structure and function, and they more precisely resemb...

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Bibliographic Details
Published in:Molecular brain 2024-08, Vol.17 (1), p.53-14, Article 53
Main Authors: Su, Ying, Liu, Aimei, Chen, Hongguang, Chen, Qingjie, Zhao, Bo, Gao, Runze, Zhang, Kangwei, Peng, Tie, Zhang, Zhenwang, Ouyang, Changhan, Zhu, Dan
Format: Article
Language:English
Subjects:
Analysis
Animals
Biomedical Research
Brain
Brain - pathology
Brain organoids
Brain research
Development and progression
Diabetes
Diabetes Mellitus - pathology
Embryonic stem cells
Gene editing
Humans
Induced Pluripotent Stem Cells - cytology
Organoids - pathology
Pluripotent stem cells
Retinopathy
Review
Type 2 diabetes
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Summary:Human embryonic stem cells and human induced pluripotent stem cells may be used to create 3D tissues called brain organoids. They duplicate the physiological and pathological characteristics of human brain tissue more faithfully in terms of both structure and function, and they more precisely resemble the morphology and cellular structure of the human embryonic brain. This makes them valuable models for both drug screening and in vitro studies on the development of the human brain and associated disorders. The technical breakthroughs enabled by brain organoids have a significant impact on the research of different brain regions, brain development and sickness, the connections between the brain and other tissues and organs, and brain evolution. This article discusses the development of brain organoids, their use in diabetes research, and their progress.
ISSN:1756-6606
1756-6606
DOI:10.1186/s13041-024-01123-4