Epidemiological Characterization of Clinical Fungal Isolates from Pauls Stradinš Clinical University Hospital, Latvia: A 4-Year Surveillance Report

Nosocomial fungal infections are an emerging global public health threat that requires urgent attention and proper management. With the limited availability of treatment options, it has become necessary to understand the emerging epidemiological trends, mechanisms, and risk factors. However, very li...

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Bibliographic Details
Published in:Life (Basel, Switzerland) Switzerland), 2021-09, Vol.11 (10), p.1002
Main Authors: Jain, Nityanand, Jansone, Inese, Obidenova, Tatjana, Sīmanis, Raimonds, Meisters, Jānis, Straupmane, Dagnija, Reinis, Aigars
Format: Article
Language:English
Subjects:
Antifungal agents
antifungal resistance
antifungals
Antimicrobial agents
Bronchus
Candida
Candidemia
Drug dosages
Enzymes
Epidemiology
Fungal infections
Fungi
Fungicides
Health risks
Hospitals
Laboratories
Lung diseases
Nosocomial infection
Nosocomial infections
opportunistic infections
Patients
Pesticides
Public health
Risk analysis
Risk factors
Sputum
Thorax
Trends
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Summary:Nosocomial fungal infections are an emerging global public health threat that requires urgent attention and proper management. With the limited availability of treatment options, it has become necessary to understand the emerging epidemiological trends, mechanisms, and risk factors. However, very limited surveillance reports are available in the Latvian and broader European context. We therefore conducted a retrospective analysis of laboratory data (2017-2020) from Pauls Stradinš Clinical University Hospital (PSCUH), Riga, Latvia, which is one of the largest public multispecialty hospitals in Latvia. A total of 2278 fungal isolates were analyzed during the study period, with spp. comprising 95% of the isolates, followed by spp. and spp. Amongst the spp., and made up about 75% of the isolates. The Department of Lung Diseases and Thoracic Surgery had the highest caseload followed by Intensive Care Department. Majority of the fungal isolates were collected from the bronchoalveolar lavage (37%), followed by urine (19%) and sputum (18%) samples. A total of 34 cases of candidemia were noted during the study period with being the most common candidemia pathogen. Proper surveillance of emerging epidemiological trends serve as the most reliable and powerful cornerstone towards tackling this emerging threat.
ISSN:2075-1729
2075-1729
DOI:10.3390/life11101002