Molecular and Cellular Mechanisms of Vascular Development in Zebrafish

The establishment of a functional cardiovascular system is crucial for the development of all vertebrates. Defects in the development of the cardiovascular system lead to cardiovascular diseases, which are among the top 10 causes of death worldwide. However, we are just beginning to understand which...

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Bibliographic Details
Published in:Life (Basel, Switzerland) Switzerland), 2021-10, Vol.11 (10), p.1088
Main Authors: Eberlein, Jean, Herdt, Lukas, Malchow, Julian, Rittershaus, Annegret, Baumeister, Stefan, Helker, Christian SM
Format: Article
Language:English
Subjects:
Angiogenesis
Blood vessels
Cardiovascular diseases
Cardiovascular system
Cell cycle
Danio rerio
Embryos
endothelial cells
Genes
Genomes
Kinases
Ligands
Molecular modelling
Organs
Phosphorylation
Proteins
Review
signaling pathways
Transcription factors
Vascular endothelial growth factor
vasculogenesis
Veins & arteries
Vertebrates
Zebrafish
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Summary:The establishment of a functional cardiovascular system is crucial for the development of all vertebrates. Defects in the development of the cardiovascular system lead to cardiovascular diseases, which are among the top 10 causes of death worldwide. However, we are just beginning to understand which signaling pathways guide blood vessel growth in different tissues and organs. The advantages of the model organism zebrafish (Danio rerio) helped to identify novel cellular and molecular mechanisms of vascular growth. In this review we will discuss the current knowledge of vasculogenesis and angiogenesis in the zebrafish embryo. In particular, we describe the molecular mechanisms that contribute to the formation of blood vessels in different vascular beds within the embryo.
ISSN:2075-1729
2075-1729
DOI:10.3390/life11101088