Decline in ESBL Production and Carbapenem Resistance in Urinary Tract Infections among Key Bacterial Species during the COVID-19 Pandemic

• Published in: Antibiotics (Basel) 2024-02, Vol.13 (3), p.216
• Main Authors: Altamimi, Ibraheem, Binkhamis, Khalifa, Alhumimidi, Abdullah, Alabdulkarim, Ibrahim M, Almugren, Abdulrahman, Alhemsi, Hadi, Altamimi, Abdulaziz, Almazyed, Abeer, Elbih, Seham, Alghunaim, Razan, Altamimi, Abdullah
• Format: Article
• Language: English
• Subjects: Analysis; Antibiotics; Antimicrobial resistance; Bacteria; Bacterial pneumonia; Beta lactamases; carbapenem resistance; Carbapenems; COVID-19; Development and progression; Drug resistance; Drug resistance in microorganisms; E coli; ESBL; Global health; Health aspects; Health care; Klebsiella; Methicillin; Pandemics; Pathogens; Patients; Pneumonia; Production management; Public health; Reduction; Regression analysis; Urinary tract; urinary tract infection; Urinary tract infections; β Lactamase
• ISSN: 2079-6382; 2079-6382
• DOI: 10.3390/antibiotics13030216

The COVID-19 pandemic has led to significant changes in healthcare practices, including increased antibiotic usage. This study aimed to investigate the impact of the pandemic on the prevalence of extended-spectrum β-lactamase (ESBL) production and carbapenem resistance among key bacterial species causing urinary tract infections (UTIs). Conducted at King Fahad Medical City in Riyadh from January 2018 to December 2022, the study analyzed urine samples from 9697 UTI patients. Patients were categorized into 'pre-COVID-19' and 'during COVID-19' groups. Bacterial isolates were identified, and antimicrobial susceptibility testing was performed following guidelines. ESBL production was detected using the Double-Disc Synergy Test. and were the main pathogens. During the pandemic, ESBL production decreased in by 1.9% and in by 6.0%. Carbapenem resistance also declined, with displaying a 1.2% reduction and and displaying 10.7% and 7.9% reductions, respectively. Notably, logistic regression analysis revealed that the odds of ESBL presence were 10% lower during the COVID-19 pandemic (OR 0.91; 95% CI 0.83-0.99; = 0.040), and there was a significant reduction in the odds of carbapenem resistance (OR 0.43; 95% CI 0.37-0.51; < 0.001). This study reveals a significant decrease in ESBL production and carbapenem resistance among UTI pathogens during the COVID-19 pandemic, hinting at the impact of modified antibiotic and healthcare approaches. It emphasizes the need for persistent antimicrobial resistance surveillance and policy adaptation to address resistance challenges, offering key directions for future public health actions.