Direct access to pyrido/pyrrolo[2,1-b]quinazolin-9(1H)-ones through silver-mediated intramolecular alkyne hydroamination reactions

We report a synthetic methodology for the construction of the fused heterocyclic compounds pyrido[2,1-b]quinazolin-9(1H)-ones and pyrrolo[2,1-b]quinazolin-9(1H)-ones through an AgOTf-catalyzed intramolecular alkyne hydroamination reaction. The methodology is applicable to a wide scope of substrates...

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Bibliographic Details
Published in:Beilstein journal of organic chemistry 2015-03, Vol.11 (1), p.416-424
Main Authors: Wang, Hengshuai, Jiao, Shengchao, Chen, Kerong, Zhang, Xu, Zhao, Linxiang, Liu, Dan, Zhou, Yu, Liu, Hong
Format: Article
Language:English
Subjects:
Chemistry
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heterocyclic molecules
intramolecular alkyne hydroamination
silver
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Summary:We report a synthetic methodology for the construction of the fused heterocyclic compounds pyrido[2,1-b]quinazolin-9(1H)-ones and pyrrolo[2,1-b]quinazolin-9(1H)-ones through an AgOTf-catalyzed intramolecular alkyne hydroamination reaction. The methodology is applicable to a wide scope of substrates and produces a series of fused quinazolinone heterocycles in good to excellent yields.
ISSN:1860-5397
1860-5397
DOI:10.3762/bjoc.11.47