Osteomyelitis and lung abscess due to Aspergillus fumigatus in a chronic granulomatous disease patient

Background and Purpose: Chronic granulomatous disease (CGD) is an inherited disorder of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. This disorder results in recurrent life-threatening bacterial and fungal infections. Aspergillus species are the most common fungal infecti...

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Bibliographic Details
Published in:Current medical mycology 2016-09, Vol.2 (3), p.37-41
Main Authors: Mamishi, Setareh, Zomorodian, Kamiar, Saadat, Farshid, Jalali, SeyedehZohreh, Geramishoar, Mohsen
Format: Article
Language:English
Subjects:
Antifungal agents
Aspergillus
Case Report
Chronic granulomatous disease
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Summary:Background and Purpose: Chronic granulomatous disease (CGD) is an inherited disorder of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. This disorder results in recurrent life-threatening bacterial and fungal infections. Aspergillus species are the most common fungal infections in these patients. Case Report: Herein, we present a case of fungal infection in a girl with CGD. We confirmed aspergillosis through the positive microscopic and macroscopic examinations, as well as radiology results. Invasive aspergillosis in this patient with pneumonia, lung abscess, and osteomyelitis of the ribs was not initially treated with amphotericin B (Am B) and recombinant interferon-gamma. Conclusion: Among infectious diseases, fungal infections, in particular aspergillosis, remain a serious problem in CGD patients. Considering poor clinical response and deficient immune system, rapid diagnosis of fungal infection and optimizing the treatment of these patients are recommended.
ISSN:2423-3439
2423-3420
DOI:10.18869/acadpub.cmm.2.3.37