Glucose alteration and insulin resistance in asymptomatic obese children and adolescents

Obesity is associated with the abnormal glucose metabolism preceding type 2 diabetes mellitus. Thus, further investigation on the prediction of this lethal outcome must be sought. The objective was the profile glycemic assessment of asymptomatic obese children and adolescents from Salvador, Brazil....

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Bibliographic Details
Published in:Jornal de pediatria 2018-05, Vol.94 (3), p.268-272
Main Authors: Assunção, Silvana Neves Ferraz de, Boa Sorte, Ney Christian Amaral, Alves, Crésio de Aragão Dantas, Mendes, Patricia S. Almeida, Alves, Carlos Roberto Brites, Silva, Luciana Rodrigues
Format: Article
Language:English
Subjects:
Adolescent
Asymptomatic Diseases
Blood glucose
Blood Glucose - analysis
Body Mass Index
Child
Diabetes mellitus
Female
Glicemia
Glucose Tolerance Test
Hiperglicemia
Humans
Hyperglycemia
Hyperinsulinism - blood
Hyperinsulinism - diagnosis
Hyperinsulinism - etiology
Insulin Resistance - physiology
Male
Obesidade
Obesity
Obesity - blood
Obesity - complications
Obesity - physiopathology
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Summary:Obesity is associated with the abnormal glucose metabolism preceding type 2 diabetes mellitus. Thus, further investigation on the prediction of this lethal outcome must be sought. The objective was the profile glycemic assessment of asymptomatic obese children and adolescents from Salvador, Brazil. A fasting venous blood sample was obtained from 90 consecutive obese individuals aged 8–18 years, of both sexes, for laboratory determinations of glycated hemoglobin, basal insulin, and the Homeostasis Model Assessment Insulin Resistance index. The clinical evaluation included weight, height, waist circumference, assessment of pubertal development, and acanthosis nigricans research. The body mass index/age indicator was used for the severity of overweight assessment. Glycemic alterations were evidenced clinically and biochemically, although these individuals had no complaints or symptoms related to blood sugar levels. Quantitative and qualitative variables were respectively expressed measures of central tendency/dispersion and simple/relative frequency, using the SPSS, version 20.0. A p-value
ISSN:0021-7557
1678-4782
1678-4782
DOI:10.1016/j.jped.2017.06.008