C-reactive protein and clinical subtypes of major depressive disorder at Zagazig University Hospitals

Background Although, the relation between inflammation and major depressive disorder (MDD) looks like firm, it may not exist in all patients with depression. Therefore, the main aim of this study was to compare serum C-reactive protein (CRP) level among clinical subtypes of MDD and its relation with...

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Published in:Middle East current psychiatry (Cairo) 2020-07, Vol.27 (1), p.1-7, Article 35
Main Authors: Mohamed, Amany Elshabrawy, El-Latif, Rafik Reda Abd, Youssef, Amira Mohamed, Ibrahim, Abdallah Saad
Format: Article
Language:English
Subjects:
Age
Body mass index
C-reactive protein
Cytokines
Depression subtypes
Education
Females
Inflammation
Medicine
Medicine & Public Health
Mental depression
Mental disorders
Outpatient care facilities
Patients
Proteins
Psychiatry
Psychosis
Quantitative psychology
Suicidal behavior
Suicidality
Suicides & suicide attempts
Trauma
Variables
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Summary:Background Although, the relation between inflammation and major depressive disorder (MDD) looks like firm, it may not exist in all patients with depression. Therefore, the main aim of this study was to compare serum C-reactive protein (CRP) level among clinical subtypes of MDD and its relation with suicidality. Results According to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for MDD, 98 patients included and categorized into five clinical subtypes groups: atypical, anxious, melancholic, psychotic, and unspecified depression with percent (11.2%, 31.6%, 19.4%, 15.3%, and 22.4%) respectively. Twenty-four (24.5%) of all patients had suicidal thoughts using Beck Scale for Suicidal Ideation (BSS) with statistically significant increase ( P < 0.05*) in suicidality among atypical group. On assessing CRP level, there was highly statistical significant increase ( P < 0.001**) among cases with atypical type and also cases with suicidal ideation. Also, logistic regression analysis found that the significant predictors for high CRP among the studied cases were smoking, suicidality, atypical depression, and suicide depression. Conclusions Higher level of CRP was found among patients with atypical MDD, and there was significant relationship between CRP and suicidality.
ISSN:2090-5416
2090-5408
2090-5416
DOI:10.1186/s43045-020-00038-9