Developmental vitamin D-deficiency produces autism-relevant behaviours and gut-health associated alterations in a rat model

Developmental vitamin D (DVD)-deficiency is an epidemiologically established risk factor for autism. Emerging studies also highlight the involvement of gut microbiome/gut physiology in autism. The current study aims to examine the effect of DVD-deficiency on a broad range of autism-relevant behaviou...

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Bibliographic Details
Published in:Translational psychiatry 2023-06, Vol.13 (1), p.204-204, Article 204
Main Authors: Tamang, Man Kumar, Ali, Asad, Pertile, Renata Nedel, Cui, Xiaoying, Alexander, Suzy, Nitert, Marloes Dekker, Palmieri, Chiara, Eyles, Darryl
Format: Article
Language:English
Subjects:
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Animals
Autism
Autistic Disorder - etiology
Behavior
Behavioral Sciences
Biological Psychology
Brain
Gastrointestinal Microbiome
Laboratories
Males
Medicine
Medicine & Public Health
Microbiota
Neurosciences
Pharmacotherapy
Physiology
Psychiatry
Rats
Small intestine
Software
Vitamin D
Vitamin D Deficiency - complications
Vitamin deficiency
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Summary:Developmental vitamin D (DVD)-deficiency is an epidemiologically established risk factor for autism. Emerging studies also highlight the involvement of gut microbiome/gut physiology in autism. The current study aims to examine the effect of DVD-deficiency on a broad range of autism-relevant behavioural phenotypes and gut health. Vitamin D deficient rat dams exhibited altered maternal care, DVD-deficient pups showed increased ultrasonic vocalizations and as adolescents, social behaviour impairments and increased repetitive self-grooming behaviour. There were significant impacts of DVD-deficiency on gut health demonstrated by alterations to the microbiome, decreased villi length and increased ileal propionate levels. Overall, our animal model of this epidemiologically validated risk exposure for autism shows an expanded range of autism-related behavioural phenotypes and now alterations in gut microbiome that correlate with social behavioural deficits raising the possibility that DVD-deficiency induced ASD-like behaviours are due to alterations in gut health.
ISSN:2158-3188
2158-3188
DOI:10.1038/s41398-023-02513-3