Comparison of ERG11 gene expression profiles of Candida albicans treated with Thymus vulgaris extracts alone and in combination with Mentha spicata

Introduction:Diseases caused by opportunistic pathogen Candida albicans are usually treated with antifungal drugs, but treatment failure is not uncommon especially in profoundly immunocompromised hosts. The aim of this study was to compare erg gene expression profiles of Candida albicans treated wit...

Full description

Saved in:
Bibliographic Details
Published in:Zīstʹshināsī-i mīkrūʹurgānīsmʹhā : Biological journal of microorganism 2018-03, Vol.7 (25), p.87-99
Main Authors: Alireza Khodavandi, Fahimeh Alizadeh, Zeynab Abrahe
Format: Article
Language:English
Subjects:
Candida albicans
ERG11
Gene expression
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 99
container_issue 25
container_start_page 87
container_title Zīstʹshināsī-i mīkrūʹurgānīsmʹhā : Biological journal of microorganism
container_volume 7
creator Alireza Khodavandi
Fahimeh Alizadeh
Zeynab Abrahe
description Introduction:Diseases caused by opportunistic pathogen Candida albicans are usually treated with antifungal drugs, but treatment failure is not uncommon especially in profoundly immunocompromised hosts. The aim of this study was to compare erg gene expression profiles of Candida albicans treated with Thymus vulgaris extracts alone and in combination with Mentha spicata. Materials and methods: In this cross- sectional study, using volume based analyses we have conducted a gene expression profiling of ERG11 gene in C. albicans treated with Thymus vulgaris extracts alone and in combination with Mentha spicata. Results: Analysis of gene expression profiles revealed the decrease of ERG11 in C. albicans treated with Thymus vulgaris extracts in combination with Mentha spicata. Incubation with Thymus vulgaris and Mentha spicata extracts alone, however, resulted in a decrease in ERG11 RNA levels less than combination. Discussion and conclusion: These data suggest a common mechanism to find the probable targets e.g., in response to ergosterol depletion in C. albicans treated with Thymus vulgaris extracts alone and in combination with Mentha spicata.
doi_str_mv 10.22108/bjm.2018.21758
format article
fullrecord <record><control><sourceid>doaj</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_64de53117ddb4bc3bfaadd9e0e10d884</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_64de53117ddb4bc3bfaadd9e0e10d884</doaj_id><sourcerecordid>oai_doaj_org_article_64de53117ddb4bc3bfaadd9e0e10d884</sourcerecordid><originalsourceid>FETCH-doaj_primary_oai_doaj_org_article_64de53117ddb4bc3bfaadd9e0e10d8843</originalsourceid><addsrcrecordid>eNqtzE1OwzAQBWALgUQFXbP1BRpsJ2nMOio_Czao-2gcTxJHiR3ZLtBzcGHcCnGCrmY0895HyANnmRCcyUc1zplgXGaCV6W8IiuRC7EpueTX_3uV35J1CCNjjIstE0W5Ij-1mxfwJjhLXUd3Hy-c0x4tUvxePIZg0mPxrjMThlOiBquNBgqTMi3YQKNHiKjpl4kD3Q_H-RDo52HqT2hCooc2hhR3yUxdaixt3ayMhXiyz7V3tHEAGpZERrgnNx1MAdd_8468Pe_29etGOxibxZsZ_LFxYJrzwfm-AR9NO2GzLTSWOeeV1qpQba46AK2fkCFnWsoiv6T1C8pdemI</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Comparison of ERG11 gene expression profiles of Candida albicans treated with Thymus vulgaris extracts alone and in combination with Mentha spicata</title><source>Publicly Available Content Database</source><creator>Alireza Khodavandi ; Fahimeh Alizadeh ; Zeynab Abrahe</creator><creatorcontrib>Alireza Khodavandi ; Fahimeh Alizadeh ; Zeynab Abrahe</creatorcontrib><description>Introduction:Diseases caused by opportunistic pathogen Candida albicans are usually treated with antifungal drugs, but treatment failure is not uncommon especially in profoundly immunocompromised hosts. The aim of this study was to compare erg gene expression profiles of Candida albicans treated with Thymus vulgaris extracts alone and in combination with Mentha spicata. Materials and methods: In this cross- sectional study, using volume based analyses we have conducted a gene expression profiling of ERG11 gene in C. albicans treated with Thymus vulgaris extracts alone and in combination with Mentha spicata. Results: Analysis of gene expression profiles revealed the decrease of ERG11 in C. albicans treated with Thymus vulgaris extracts in combination with Mentha spicata. Incubation with Thymus vulgaris and Mentha spicata extracts alone, however, resulted in a decrease in ERG11 RNA levels less than combination. Discussion and conclusion: These data suggest a common mechanism to find the probable targets e.g., in response to ergosterol depletion in C. albicans treated with Thymus vulgaris extracts alone and in combination with Mentha spicata.</description><identifier>ISSN: 2322-5173</identifier><identifier>EISSN: 2322-5181</identifier><identifier>DOI: 10.22108/bjm.2018.21758</identifier><language>eng</language><publisher>University of Isfahan</publisher><subject>Candida albicans ; ERG11 ; Gene expression</subject><ispartof>Zīstʹshināsī-i mīkrūʹurgānīsmʹhā : Biological journal of microorganism, 2018-03, Vol.7 (25), p.87-99</ispartof><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Alireza Khodavandi</creatorcontrib><creatorcontrib>Fahimeh Alizadeh</creatorcontrib><creatorcontrib>Zeynab Abrahe</creatorcontrib><title>Comparison of ERG11 gene expression profiles of Candida albicans treated with Thymus vulgaris extracts alone and in combination with Mentha spicata</title><title>Zīstʹshināsī-i mīkrūʹurgānīsmʹhā : Biological journal of microorganism</title><description>Introduction:Diseases caused by opportunistic pathogen Candida albicans are usually treated with antifungal drugs, but treatment failure is not uncommon especially in profoundly immunocompromised hosts. The aim of this study was to compare erg gene expression profiles of Candida albicans treated with Thymus vulgaris extracts alone and in combination with Mentha spicata. Materials and methods: In this cross- sectional study, using volume based analyses we have conducted a gene expression profiling of ERG11 gene in C. albicans treated with Thymus vulgaris extracts alone and in combination with Mentha spicata. Results: Analysis of gene expression profiles revealed the decrease of ERG11 in C. albicans treated with Thymus vulgaris extracts in combination with Mentha spicata. Incubation with Thymus vulgaris and Mentha spicata extracts alone, however, resulted in a decrease in ERG11 RNA levels less than combination. Discussion and conclusion: These data suggest a common mechanism to find the probable targets e.g., in response to ergosterol depletion in C. albicans treated with Thymus vulgaris extracts alone and in combination with Mentha spicata.</description><subject>Candida albicans</subject><subject>ERG11</subject><subject>Gene expression</subject><issn>2322-5173</issn><issn>2322-5181</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNqtzE1OwzAQBWALgUQFXbP1BRpsJ2nMOio_Czao-2gcTxJHiR3ZLtBzcGHcCnGCrmY0895HyANnmRCcyUc1zplgXGaCV6W8IiuRC7EpueTX_3uV35J1CCNjjIstE0W5Ij-1mxfwJjhLXUd3Hy-c0x4tUvxePIZg0mPxrjMThlOiBquNBgqTMi3YQKNHiKjpl4kD3Q_H-RDo52HqT2hCooc2hhR3yUxdaixt3ayMhXiyz7V3tHEAGpZERrgnNx1MAdd_8468Pe_29etGOxibxZsZ_LFxYJrzwfm-AR9NO2GzLTSWOeeV1qpQba46AK2fkCFnWsoiv6T1C8pdemI</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Alireza Khodavandi</creator><creator>Fahimeh Alizadeh</creator><creator>Zeynab Abrahe</creator><general>University of Isfahan</general><scope>DOA</scope></search><sort><creationdate>20180301</creationdate><title>Comparison of ERG11 gene expression profiles of Candida albicans treated with Thymus vulgaris extracts alone and in combination with Mentha spicata</title><author>Alireza Khodavandi ; Fahimeh Alizadeh ; Zeynab Abrahe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-doaj_primary_oai_doaj_org_article_64de53117ddb4bc3bfaadd9e0e10d8843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Candida albicans</topic><topic>ERG11</topic><topic>Gene expression</topic><toplevel>online_resources</toplevel><creatorcontrib>Alireza Khodavandi</creatorcontrib><creatorcontrib>Fahimeh Alizadeh</creatorcontrib><creatorcontrib>Zeynab Abrahe</creatorcontrib><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Zīstʹshināsī-i mīkrūʹurgānīsmʹhā : Biological journal of microorganism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alireza Khodavandi</au><au>Fahimeh Alizadeh</au><au>Zeynab Abrahe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of ERG11 gene expression profiles of Candida albicans treated with Thymus vulgaris extracts alone and in combination with Mentha spicata</atitle><jtitle>Zīstʹshināsī-i mīkrūʹurgānīsmʹhā : Biological journal of microorganism</jtitle><date>2018-03-01</date><risdate>2018</risdate><volume>7</volume><issue>25</issue><spage>87</spage><epage>99</epage><pages>87-99</pages><issn>2322-5173</issn><eissn>2322-5181</eissn><abstract>Introduction:Diseases caused by opportunistic pathogen Candida albicans are usually treated with antifungal drugs, but treatment failure is not uncommon especially in profoundly immunocompromised hosts. The aim of this study was to compare erg gene expression profiles of Candida albicans treated with Thymus vulgaris extracts alone and in combination with Mentha spicata. Materials and methods: In this cross- sectional study, using volume based analyses we have conducted a gene expression profiling of ERG11 gene in C. albicans treated with Thymus vulgaris extracts alone and in combination with Mentha spicata. Results: Analysis of gene expression profiles revealed the decrease of ERG11 in C. albicans treated with Thymus vulgaris extracts in combination with Mentha spicata. Incubation with Thymus vulgaris and Mentha spicata extracts alone, however, resulted in a decrease in ERG11 RNA levels less than combination. Discussion and conclusion: These data suggest a common mechanism to find the probable targets e.g., in response to ergosterol depletion in C. albicans treated with Thymus vulgaris extracts alone and in combination with Mentha spicata.</abstract><pub>University of Isfahan</pub><doi>10.22108/bjm.2018.21758</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2322-5173
ispartof Zīstʹshināsī-i mīkrūʹurgānīsmʹhā : Biological journal of microorganism, 2018-03, Vol.7 (25), p.87-99
issn 2322-5173
2322-5181
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_64de53117ddb4bc3bfaadd9e0e10d884
source Publicly Available Content Database
subjects Candida albicans
ERG11
Gene expression
title Comparison of ERG11 gene expression profiles of Candida albicans treated with Thymus vulgaris extracts alone and in combination with Mentha spicata
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T06%3A07%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-doaj&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20ERG11%20gene%20expression%20profiles%20of%20Candida%20albicans%20treated%20with%20Thymus%20vulgaris%20extracts%20alone%20and%20in%20combination%20with%20Mentha%20spicata&rft.jtitle=Z%C4%ABst%CA%B9shin%C4%81s%C4%AB-i%20m%C4%ABkr%C5%AB%CA%B9urg%C4%81n%C4%ABsm%CA%B9h%C4%81%20:%20Biological%20journal%20of%20microorganism&rft.au=Alireza%20Khodavandi&rft.date=2018-03-01&rft.volume=7&rft.issue=25&rft.spage=87&rft.epage=99&rft.pages=87-99&rft.issn=2322-5173&rft.eissn=2322-5181&rft_id=info:doi/10.22108/bjm.2018.21758&rft_dat=%3Cdoaj%3Eoai_doaj_org_article_64de53117ddb4bc3bfaadd9e0e10d884%3C/doaj%3E%3Cgrp_id%3Ecdi_FETCH-doaj_primary_oai_doaj_org_article_64de53117ddb4bc3bfaadd9e0e10d8843%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true