The dorsal skinfold chamber: A versatile tool for preclinical research in tissue engineering and regenerative medicine

The dorsal skinfold chamber is a rodent model for non-invasive microcirculatory analyses of striated muscle and skin tissue throughout an observation period of 2-3 weeks. In combination with intravital fluorescence microscopy, this model allows the quantitative assessment of dynamic processes such a...

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Bibliographic Details
Published in:European cells & materials 2016-09, Vol.32, p.202-215
Main Authors: Laschke, M W, Menger, M D
Format: Article
Language:English
Subjects:
angiogenesis
Animals
biocompatibility
dermal substitute
flap
inflammation
microcirculation
Prostheses and Implants
Regenerative Medicine - methods
scaffold
skin
Skin - blood supply
Skin Transplantation
Tissue engineering
Tissue Engineering - methods
Wound Healing
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Summary:The dorsal skinfold chamber is a rodent model for non-invasive microcirculatory analyses of striated muscle and skin tissue throughout an observation period of 2-3 weeks. In combination with intravital fluorescence microscopy, this model allows the quantitative assessment of dynamic processes such as inflammation, angiogenesis, vascular remodelling and microcirculation. Accordingly, the dorsal skinfold chamber is increasingly used for preclinical research in tissue engineering and regenerative medicine. This includes studies on biocompatibility, vascularisation and incorporation of medical implants and artificial tissue constructs. Moreover, the chamber implantation procedure has been modified to analyse primary and secondary wound healing as well as revascularisation and blood perfusion of dermal substitutes, skin grafts and myocutaneous flaps. Hence, the dorsal skinfold chamber model does not only provide deep insights into fundamental regenerative mechanisms but also represents a versatile tool for the development of novel therapeutic strategies.
ISSN:1473-2262
DOI:10.22203/eCM.v032a13