Synthesis of an ent-halimanolide from ent-halimic acid

An efficient synthesis of ent-halimanolide 2 (15,16-epoxy-12-oxo-ent-halima- 5(10),13(16),14-trien-18,2beta-olide), from ent-halimic acid has been achieved, corroborating the structure of the natural compound and establishing its absolute configuration.

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Published in:Molecules (Basel, Switzerland) Switzerland), 2008-05, Vol.13 (5), p.1120-1134
Main Authors: Marcos, Isidro S, Conde, Almudena, Moro, Rosalina F, Basabe, Pilar, Díez, David, Mollinedo, Faustino, Urones, Julio G
Format: Article
Language:English
Subjects:
Acids
Cladogynos orientalis
Diterpenes - chemical synthesis
Diterpenes - chemistry
diterpenoids
Ent-halimanolides
ent-halimic acid
Euphorbiaceae - chemistry
Oxidation
Physical properties
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cited_by cdi_FETCH-LOGICAL-c491t-4e006bc64347e59b6f20597dd27332a24441ead911e32a0a1de32e3e05898c243
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container_issue 5
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container_title Molecules (Basel, Switzerland)
container_volume 13
creator Marcos, Isidro S
Conde, Almudena
Moro, Rosalina F
Basabe, Pilar
Díez, David
Mollinedo, Faustino
Urones, Julio G
description An efficient synthesis of ent-halimanolide 2 (15,16-epoxy-12-oxo-ent-halima- 5(10),13(16),14-trien-18,2beta-olide), from ent-halimic acid has been achieved, corroborating the structure of the natural compound and establishing its absolute configuration.
doi_str_mv 10.3390/molecules13051120
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subjects Acids
Cladogynos orientalis
Diterpenes - chemical synthesis
Diterpenes - chemistry
diterpenoids
Ent-halimanolides
ent-halimic acid
Euphorbiaceae - chemistry
Oxidation
Physical properties
title Synthesis of an ent-halimanolide from ent-halimic acid
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