Factor XI Deficiency Case Reports on Congenital and Acquired Hemophilia C - A Case Report

Introduction: Factor XI deficiency or hemophilia C is a very rare coagulation factor deficiency, with a global incidence of 1 in 1 million. Although it is an under-recognized entity, it can cause significant bleeding, resulting in life-threatening complications. Materials and Methods: Coagulation pa...

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Bibliographic Details
Published in:Apollo medicine 2022-12, Vol.19 (4), p.267-269
Main Authors: Soni, Mamta, Muralikrishnan, Srikanth, Sundaram, Supraja
Format: Article
Language:English
Subjects:
acquired hemophilia
factor inhibitors
factor xi deficiency
hemophilia c
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Summary:Introduction: Factor XI deficiency or hemophilia C is a very rare coagulation factor deficiency, with a global incidence of 1 in 1 million. Although it is an under-recognized entity, it can cause significant bleeding, resulting in life-threatening complications. Materials and Methods: Coagulation parameters were analyzed using a Sysmex CS-2400 coagulation analyzer. Factor XI levels were detected using Factor XI deficient plasma from Siemens. Activated Partial Thromboplastin Time (APTT) testing was performed using Actin FSL from Siemens. Results: Here, we report the two cases of Factor XI deficiency, one genetic and the other a very rare acquired deficiency due to sepsis, detected during the workup of an isolated APTT prolongation. Conclusion: Factor XI deficiency is a rare bleeding disorder that presents as prolonged isolated APTT. Careful clinical evaluation and complete coagulation workup are necessary for the efficient management of patients, which can prevent life-threatening events.
ISSN:0976-0016
2213-3682
DOI:10.4103/am.am_108_22