Anxiety in Mice: A Principal Component Analysis Study

Two principal component analyses of anxiety were undertaken investigating two strains of mice (ABP/Le and C57BL/6ByJ) in two different experiments, both classical tests for assessing anxiety in rodents. The elevated plus-maze and staircase were used for the first experiment, and a free exploratory p...

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Bibliographic Details
Published in:Journal of Neural Transplantation & Plasticity 2007, Vol.2007, p.361-368
Main Authors: Clément, Yan, Joubert, Chantal, Kopp, Caroline, Lepicard, Eve M, Venault, Patrice, Misslin, René, Cadot, Martine, Chapouthier, Georges
Format: Article
Language:English
Subjects:
Animals
Anxiety
Anxiety - genetics
Anxiety - physiopathology
Anxiety - psychology
Behavior
Exploratory Behavior - physiology
Female
Genetic aspects
Life Sciences
Male
Mathematics
Mice
Mice - genetics
Mice - psychology
Mice, Inbred C57BL
Neurons and Cognition
Neurosciences
Physiological aspects
Principal Component Analysis - methods
Psychology and behavior
Species Specificity
Statistics
Statistics Theory
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Summary:Two principal component analyses of anxiety were undertaken investigating two strains of mice (ABP/Le and C57BL/6ByJ) in two different experiments, both classical tests for assessing anxiety in rodents. The elevated plus-maze and staircase were used for the first experiment, and a free exploratory paradigm and light-dark discrimination were used for the second. The components in the analyses produced definitions of four fundamental behavior patterns: novelty-induced anxiety, general activity, exploratory behavior, and decision making. We also noted that the anxious phenotype was determined by both strain and experimental procedure. The relationship between behavior patterns and the use of specific tests plus links with the genetic background are discussed.
ISSN:0792-8483
2090-5904
1687-5443
1687-5443
DOI:10.1155/2007/35457