Biomarkers for Prostate Cancer: From Diagnosis to Treatment

Prostate cancer (PCa) is a widespread malignancy with global significance, which substantially affects cancer-related mortality. Its spectrum varies widely, from slow-progressing cases to aggressive or even lethal forms. Effective patient stratification into risk groups is crucial to therapeutic dec...

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Bibliographic Details
Published in:Diagnostics (Basel) 2023-10, Vol.13 (21), p.3350
Main Authors: Chen, Jia-Yan, Wang, Pei-Yan, Liu, Ming-Zhu, Lyu, Feng, Ma, Ming-Wei, Ren, Xue-Ying, Gao, Xian-Shu
Format: Article
Language:English
Subjects:
4K score
Accuracy
Acids
Antimitotic agents
Antineoplastic agents
Biological markers
Biomarkers
Biopsy
Cancer
Care and treatment
Decipher
Development and progression
Diagnosis
Fatalities
Forecasts and trends
MicroRNA
Mortality
Patients
PCA3
Peptides
PHI
Prostate cancer
Risk assessment
Surveillance
Tumors
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Summary:Prostate cancer (PCa) is a widespread malignancy with global significance, which substantially affects cancer-related mortality. Its spectrum varies widely, from slow-progressing cases to aggressive or even lethal forms. Effective patient stratification into risk groups is crucial to therapeutic decisions and clinical trials. This review examines a wide range of diagnostic and prognostic biomarkers, several of which are integrated into clinical guidelines, such as the PHI, the 4K score, PCA3, Decipher, and Prolaris. It also explores the emergence of novel biomarkers supported by robust preclinical evidence, including urinary miRNAs and isoprostanes. Genetic alterations frequently identified in PCa, including BRCA1/BRCA2, ETS gene fusions, and AR changes, are also discussed, offering insights into risk assessment and precision treatment strategies. By evaluating the latest developments and applications of PCa biomarkers, this review contributes to an enhanced understanding of their role in disease management.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics13213350