Synthesis, characterization and antibacterial studies of metal complexes of sulfadiazine with N-alkyl-N-phenyldithiocarbamate

Co(II), Cu(II), Pd(II) and Pt(II) complexes of 4-amino-N-(2-pyrimidinyl)benzene sulfonamide (sulfadiazine) with some N-alkyl-N-phenyl dithiocarbamate have been synthesized and characterized by elemental analysis, conductivity measurements, UV-Vis and FTIR spectroscopy. The complexes are formulated a...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of the Chemical Society of Ethiopia 2013-01, Vol.27 (1), p.77-84
Main Authors: Ajibade, Peter A, Idemudia, Omoruyi G, Okoh, Anthony I
Format: Article
Language:English
Subjects:
Alkyl groups
Analysis
Antibacterial
Benzene
Chemical properties
Cobalt
Dithiocarbamate
Drug resistance
Electric properties
Metal complexes
Nitrogen (Chemical element)
Palladium
Sulfadiane
Sulfadiazine
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Co(II), Cu(II), Pd(II) and Pt(II) complexes of 4-amino-N-(2-pyrimidinyl)benzene sulfonamide (sulfadiazine) with some N-alkyl-N-phenyl dithiocarbamate have been synthesized and characterized by elemental analysis, conductivity measurements, UV-Vis and FTIR spectroscopy. The complexes are formulated as four coordinate M[N.sub.2][S.sub.2] species in which the metal ions are coordinated to one molecule of sulfadiazine through the pyrimidinyl and sulfulnamido nitrogen atoms and one molecule of dithiocarbamate through two sulfur atoms with both molecules acting as bidentate chelating ligands. The in vitro antibacterial activities of the complexes and sulfadiazine were evaluated against eight bacteria strains using the agar well diffusion method. The metal complexes showed varied antibacterial properties and their minimum inhibitory concentration (MIC) and maximum bactericidal concentration (MBC) were determined. KEY WORDS: Sulfadiane, Dithiocarbamate, Metal complexes, Antibacterial, Drug resistance
ISSN:1011-3924
1011-3924
1726-801X
DOI:10.4314/bcse.v27i1.8