An umbrella review of socioeconomic status and cancer

Extensive evidence underscores the pivotal role of socioeconomic status (SES) in shaping cancer-related outcomes. However, synthesizing definitive and actionable insights from the expansive body of literature remains a significant challenge. To elucidate the associations between SES, cancer outcomes...

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Bibliographic Details
Published in:Nature communications 2024-11, Vol.15 (1), p.9993-13, Article 9993
Main Authors: Li, Shen, He, Yuxin, Liu, Jifeng, Chen, Kefan, Yang, Yuzhao, Tao, Kai, Yang, Jiaqing, Luo, Kui, Ma, Xuelei
Format: Article
Language:English
Subjects:
692/700/1719
692/700/478
Breast Neoplasms - epidemiology
Cancer
Cancer screening
Cancer therapies
Colorectal carcinoma
Early Detection of Cancer
Female
Healthcare Disparities
Humanities and Social Sciences
Humans
Immunotherapy
Incidence
Lung cancer
Male
Medical screening
Melanoma
Meta-analysis
multidisciplinary
Neoplasms - epidemiology
Reviews
Science
Science (multidisciplinary)
Social Class
Socioeconomic factors
Socioeconomic status
Socioeconomics
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Summary:Extensive evidence underscores the pivotal role of socioeconomic status (SES) in shaping cancer-related outcomes. However, synthesizing definitive and actionable insights from the expansive body of literature remains a significant challenge. To elucidate the associations between SES, cancer outcomes, and the overall cancer burden, we conducted a comprehensive burden estimation coupled with an umbrella review of relevant meta-analyses. Our findings reveal that robust or highly suggestive meta-analytic evidence supports only a limited number of these associations. Individuals with lower SES, compared to those with higher SES, are disproportionately disadvantaged by reduced access to immunotherapy, KRAS testing for colorectal cancer, targeted cancer therapies, and precision treatments for melanoma. Additionally, they exhibit lower rates of breast cancer screening and higher incidence rates of lung cancer. Furthermore, countries with a higher Human Development Index demonstrate a substantially greater burden related cancer incidence, with this disparity being more pronounced among men than women. Socioeconomic status has been previously linked to cancer outcomes. Here, the authors use an umbrella review to identify differences in access to immunotherapy and cancer screening.
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-024-54444-2